内向整流型钾离子通道亚家族J成员11mRNA在脑胶质瘤中的表达及预测预后价值  

Expression and Prognostic Value of Inward Rectifier Potassium Channel Subfamily J Member 11mRNA in Gliomas

作　　者：王芳[1] 周开甲[2] 赵征 梁晖[1] 刘彦伟[2] WANG Fang;ZHOU Kaijia;ZHAO Zheng;LIANG Hui;LIU Yanwei(Department of Encephalopathy,People’s Hospital of Fujian University of Traditional Chinese Medicine,Fujian Provincial People’s Hospital,Fuzhou 350014,China;Department of Neurosurgery,Beijing Neurosurgical Institute,Capital Medical University,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100070,China)

机构地区：[1]福建省人民医院福建中医药大学附属人民医院脑病科,福州350014 [2]北京神经外科研究所首都医科大学附属北京天坛医院神经外科,北京100070

出　　处：《肿瘤防治研究》2022年第1期18-23,共6页Cancer Research on Prevention and Treatment

摘　　要：目的分析KCNJ11 mRNA在脑胶质瘤中的表达及其预测预后价值。方法收集CGGA数据库中273例脑胶质瘤患者临床、组织病理及分子病理特征,分析不同类型患者KCNJ11 mRNA表达差异,以及不同亚型患者中KCNJ11 mRNA高表达与低表达患者生存时间差异。结果脑胶质瘤患者年龄越大KCNJ11 mRNA表达越低(P=0.008),原发胶质瘤KCNJ11 mRNA表达高于复发胶质瘤(P=0.001)。少枝胶质细胞瘤KCNJ11 mRNA表达>星形细胞瘤>胶质母细胞瘤(P=0.000)。WHOⅡ级KCNJ11 mRNA表达>WHOⅢ级>WHOⅣ级(P=0.000)。IDH突变型KCNJ11 mRNA表达高于IDH野生型(P=0.000)。1p/19q缺失型KCNJ11 mRNA表达高于1p/19q不缺失型(P=0.000)。MGMT甲基化KCNJ11 mRNA高于无甲基化(P=0.036)。KCNJ11 mRNA高表达患者(≥2.77)生存期长于低表达患者(<2.77)(P=0.000)。多因素Cox分析提示KCNJ11 mRNA高表达是脑胶质瘤患者良好预后的独立影响因素。结论脑胶质瘤恶性程度越高,KCNJ11 mRNA表达越低。KCNJ11 mRNA高表达是影响脑胶质瘤患者良好预后的独立影响因素。Objective To analyze the expression of KCNJ11 mRNA in gliomas and its prognostic value.Methods The clinical,histopathological and molecular pathological features of 273 patients with gliomas were collected from CGGA.We analyzed the differences of KCNJ11 mRNA expression in different types of gliomas and the survival time of patients with high and low expression of KCNJ11 mRNA in different subtypes of gliomas.Results The expression levels of KCNJ11 mRNA in young glioma and primary glioma patients were higher than those in old glioma and recurrent glioma patients,respectively(P=0.008,0.001).The expression of KCNJ11 mRNA in oligodendroglioma was the highest,astrocytoma was the second,and glioblastoma was the lowest(P=0.000).The expression of KCNJ11 mRNA in WHOⅡgrade glioma was the highest,WHOⅢwas the second,and WHOⅣwas the lowest(P=0.000).The expression levels of KCNJ11 mRNA in IDH-mutant type glioma patients were higher than those in IDH-wild type glioma patients(P=0.000).The expression of KCNJ11 mRNA in deletion of 1p/19q glioma patients was higher than that in non-deletion of 1p/19q ones(P=0.000).The expression of KCNJ11 mRNA in MGMT methylated glioma patients was higher than that in non-methylated ones(P=0.036).The survival time of patients with high expression of KCNJ11 mRNA(≥2.77)was longer than that with low expression(P=0.000).Multivariate Cox analysis showed that the high expression of KCNJ11 mRNA was an independent factor affecting the good prognosis of patients with glioma.Conclusion The expression of KCNJ11 mRNA is negatively related to the malignant degree of the tumor.The high expression of KCNJ11 mRNA is an independent factor affecting the good prognosis of patients with glioma.

关 键 词：脑胶质瘤 KCNJ11 分子分型 作用机制 

分 类 号：R739.41[医药卫生—肿瘤]