速激肽家族及其受体在结直肠癌发生发展中的作用及研究进展  

The role and research progress of tachykinin family and its receptors in the pathogenesis and development of colorectal cancer

作　　者：黄一燊 王斌[1,2] 贾漪涛[1,2] HUANG Yishen;WANG Bin;JIA Yitao(Graduate School of Hebei Medical University, Shijiazhuang 050017, China)

机构地区：[1]河北医科大学研究生院,石家庄050017 [2]河北省人民医院肿瘤三科,050051

出　　处：《临床肿瘤学杂志》2022年第1期83-87,共5页Chinese Clinical Oncology

摘　　要：速激肽(TKS)是一类主要由中枢及外周神经元产生及分泌的神经肽,通过与其特异性受体结合来介导体内众多生理和病理过程。近年来发现TKS家族及其受体在结直肠癌的发生发展中发挥着多种生物学效应,包括参与结直肠癌的发病;某些成员如P物质及神经激肽1受体(NK1R)能促进肿瘤细胞增殖,诱导肿瘤血管生成,还可作为判断预后的潜在指标。另外,NK1R拮抗剂可通过高选择性地与受体结合,阻断P物质,起到抗肿瘤和改善化疗相关恶心呕吐的作用。本文就此作一综述。Tachykinins are neuropeptides mainly secreted by central and peripheral neurons,which mediate many physiological and pathological processes by binding to their specific receptors.In recent years,it has been found that the tachykinin family and receptors play a variety of biological effects in the occurrence and development of colorectal cancer,including participating in the pathogenesis of colorectal cancer.Some members,such as substance P and neurokinin 1 receptor(NK1R),can promote tumor cell proliferation and induce tumor angiogenesis.It can also be used as a potential indicator of prognosis.In addition,NK1R antagonist can block substance P through highly selective binding to the receptor,which plays a role in anti-tumor and improving chemotherapy-related nausea and vomiting.This article makes a summary of this.

关 键 词：结直肠癌 速激肽 神经激肽受体 治疗 预后 

分 类 号：R735.3[医药卫生—肿瘤]