喹硫平缓释片治疗精神分裂症的临床效果  

Clinical efficacy of quetiapine sustained release tablets in the treatment of schizophrenia

作　　者：吕燕霞 王丽娟[1] 王萍[1] 邵菊美 LYU Yanxia;WANG Lijuan;WANG Ping;SHAO Jumei(Department of Psychiatry,Tongde Hospital of Zhejiang Province,Hangzhou 311122,China)

机构地区：[1]浙江省立同德医院精神科,浙江杭州311122

出　　处：《中国现代医生》2022年第1期17-20,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2018KY319)。

摘　　要：目的 探讨喹硫平缓释片治疗精神分裂症的临床效果。方法 选择2019年6月至2020年10月在浙江省立同德医院诊断治疗的精神分裂症患者60例为研究对象,随机分为研究组与对照组,每组各30例。对照组采用氯丙嗪治疗,研究组采用喹硫平治疗,比较两组治疗前后PANSS评分,血生化水平,临床疗效及不良反应情况。结果 ①治疗后两组PANSS量表阳性症状评分、阴性症状评分、一般精神症状以及总分均显著下降,差异有统计学意义(P<0.001);治疗后,研究组阳性症状评分、阴性症状评分、一般精神症状以及总分均显著低于对照组,差异有统计学意义(P<0.001);②两组治疗前后FBG、LDL-C、HDL-C、TC水平比较,差异无统计学意义(P>0.05);组间比较差异无统计学意义(P>0.05);治疗前后研究组TG水平比较,差异无统计学意义(P>0.05);治疗后对照组TG较治疗前显著升高(P<0.05);治疗后研究组TG水平显著低于对照组,差异有统计学意义(P<0.001);③研究组临床疗效高于对照组,差异有统计学意义(P<0.05);④研究组锥体外系反应发生率显著低于对照组,差异有统计学意义(P<0.05);结论 喹硫平治疗精神分裂症效果优于氯丙嗪,并且对血脂的影响更小,锥体外系反应发生率更低。Objective To investigate the clinical efficacy of quetiapine sustained release tablets in the treatment of schizophrenia.Methods A total of 60 patients with schizophrenia diagnosed and treated in Tongde Hospital of Zhejiang Province from June 2019 to October 2020 were selected as the research objects,and they were randomly divided into a study group and a control group with 30 cases in each group.The control group was treated with chlorpromazine,while the study group was treated with quetiapine.The PANSS score,blood biochemical level,clinical effect and adverse reactions(ARs)of the two groups were compared between the two groups before and after treatment.Results①After treatment,the scores of positive symptoms,negative symptoms,general mental symptoms and total scores of PANSS scale in both groups decreased significantly,with statistically significant differences(P<0.001).After treatment,the scores of positive symptoms,negative symptoms,general mental symptoms and total scores in the study group were all significantly lower than those in the control group,with statistically significant differences(P<0.001).②There were no statistically significant differences in FBG,LDL-C,HDL-C and TC levels between the two groups before and after treatment(P>0.05).There was no statistically significant difference between the two groups(P>0.05).Before and after treatment,there was no statistically significant difference in TG levels in the study group(P>0.05).After treatment,TG level in the control group was significantly higher than that before treatment(P<0.05).After treatment,TG level in the study group was significantly lower than that in the control group,with statistically significant difference(P<0.001).③The clinical efficacy of the study group is higher than that of the control group,the difference is statistically significant(P<0.05).④The incidence of extrapyramidal reaction in the study group was significantly lower than that in the control group(P<0.05).Conclusion Quetiapine is superior to chlorpromazine in the

关 键 词：喹硫平 精神分裂症 阳性症状评分 阴性症状评分 一般精神症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]