猪源纤维蛋白粘合剂封闭结直肠切除术后系膜裂孔的初步研究报告  

The prelim inary study on Porcine Fibrin Sealant used in closing the mesocolon hiatus after colorectal resection

作　　者：崔伟[1] 李涛[1] 陈纲 李世拥 Cui Wei;Li Tao;Chen Gang;Li Shiyong(Medical Department of General Surgery,the 1st Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心普通外科医学部,北京100853

出　　处：《中华普外科手术学杂志（电子版）》2022年第1期59-62,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：解放军军队后勤科研项目(CU17J022)。

摘　　要：目的探讨使用猪源纤维蛋白粘合剂封闭结直肠切除术后系膜裂孔的临床效果。方法前瞻性纳入2018年1月至2020年12月同一医疗组收治的乙状结肠癌和中高位直肠癌患者120例的临床资料,采用随机数字表法将入组患者分为实验组与对照组,每组各60例。实验组使用猪源纤维蛋白粘合剂(倍绣胶)关闭系膜裂孔;对照组使用3-0倒刺线(强生)连续缝合关闭系膜裂孔。采用SPSS11.5软件包进行统计学处理,围手术期各项指标等计量资料用(x±s)表示,采用独立样本t检验;并发症发生情况等计数资料采用χ^(2)检验。以P<0.05为差异有统计学意义。结果实验组患者的系膜裂孔关闭时间及术后72 h引流量与对照组相比差异有统计学意义(P<0.05),而两组患者在系膜裂孔长度、术中出血量、淋巴结清扫数目、术后首次排气时间等方面相比较差异无统计学意义(P>0.05),两组患者在术后并发症方面,如术后肠梗阻、腹腔出血、吻合口漏、吻合口出血、吻合口狭窄、切口感染、肺部感染或肺不张、其他(包括下肢静脉栓塞等)等相比较差异无统计学意义(P>0.05).结论使用猪源纤维蛋白粘合剂封闭结直肠切除术后系膜裂孔便捷高效,安全可靠,值得临床推广应用。Objective To study the clinical effect of Porcine Fibrin Sealant used in closing the mesocolon hiatus after colorectal resection.Methods The 120 cases of sigmoid colon and rectal cancer treated in our hospital from Jan 2018 to Dec 2020 were analyzed.They were randomly divided into experimental group and control group,each 60 cases.The Porcine Fibrin Sealant was used to close the mesocolon hiatus after colorectal resection in the experimental group while the spiral PGA-PCL in control group.Statistical software SPSS 11.5 was used for analysis.The perioperative measurement data of the two groups were presented as(x±s),and compared with independent t test.The postoperative complications were determined byχ^(2)test.P<0.05 was considered statistically significant.Results The closing time,volume of drainage within 72 hours after operation were significantly lower in the experimental group than control group(P<0.05).No significant difference was noted between the two groups in terms of the length of mesocolon hiatus,blood loss,dissected lymph nodes,first exhaust time(P>0.05).Furthermore,there were no significant difference in the postoperative complications(P>0.05).Conclusions Closing the mesocolon hiatus after colorectal resection with Porcine Fibrin Sealant is easy and safe,which is worthy of clinical promotion.

关 键 词：纤维蛋白组织粘着剂 结直肠切除术 系膜裂孔 

分 类 号：R735.34[医药卫生—肿瘤]