帕米膦酸二钠辅助NP化疗乳腺癌骨转移对血清ICTP、OSC、OPG及尿NTX的影响  

Effects of pamidronate disodium-assisted NP chemotherapy on breast cancer bone metastasis on serum ICTP,OSC,OPG and urine NTX

作　　者：陈晓英 韩宏斌 富京 CHEN Xiao-ying;HAN Hong-bin;FU Jing(Department of Oncological Surgery,Panjin Liaohe Oilfield Gem Flower Hospital,Panjin Liaoning 124010,China;Department of Radiotherapy,Panjin Liaohe Oilfield Gem Flower Hospital,Panjin Liaoning 124010,China)

机构地区：[1]盘锦辽油宝石花医院肿瘤外科,辽宁盘锦124010 [2]盘锦辽油宝石花医院放疗科,辽宁盘锦124010

出　　处：《临床和实验医学杂志》2022年第1期54-58,共5页Journal of Clinical and Experimental Medicine

基　　金：辽宁省医学科研项目(编号:20180073);辽宁省盘锦市盘锦辽油宝石花医院科研项目(编号:KY2019026)。

摘　　要：目的探讨帕米膦酸二钠辅助NP(长春瑞滨和顺铂)方案化疗乳腺癌骨转移的效果及对血清Ⅰ型羧基末端肽(ICTP)、骨钙素(OSC)、骨保护素(OPG)、尿Ⅰ型胶原吡啶交链氨基末端肽(NTX)的影响。方法回顾性选取2015年5月至2017年5月盘锦辽油宝石花医院收治的98例晚期乳腺癌发生骨转移的患者作为研究对象,按照治疗方案不同分为两组,其中49例患者接受NP方案化疗(NP组)、另外49例患者接受NP方案+帕米膦酸二钠治疗(联合组)。比较两组的化疗效果,化疗前、治疗2个月后的血清ICTP、OSC、OPG及尿NTX水平变化,2年生存率及不良反应。结果治疗后,联合组患者的痊愈率24.49%、显效率51.02%、有效率16.33%、无效率8.16%,NP组患者的痊愈率14.29%、显效率36.73%、有效率32.65%、无效率16.33%,联合组的疗效优于NP组,差异有统计学意义(P <0.05)。治疗前,联合组和NP组患者的血清ICTP、OSC、OPG及尿NTX水平差异无统计学意义(P> 0.05);治疗2个月后联合组的ICTP、OSC、OPG尿NTX为(3.80±0.91) ng/mL、(5.84±1.26) ng/mL、(9.31±1.84) U/L、(3.73±0.77) nmol/L,均低于NP组[(4.41±1.13) ng/mL、(6.60±1.34) ng/mL、(10.58±2.01) U/L、NTX(4.46±0.93) nmol/L],差异均有统计学意义(P<0.05)。治疗过程中,联合组患者与NP组患者的骨髓抑制、恶心、呕吐、腹泻、肝肾损害、脱发发生率比较,差异均无统计学意义(P> 0.05)。随访2年,联合组和NP组患者的失访率、2年生存率比较,差异均无统计学意义(P> 0.05)。结论帕米膦酸二钠辅助NP方案治疗乳腺癌骨转移患者对于缓解患者骨痛、提高肿瘤化疗效果、改善骨代谢水平具有一定的作用,但是对于提高患者远期生存率并不明显。Objective To investigate the effect of pamidronate disodium-assisted NP regimen( vinorelbine + cisplatin) on breast cancer metastasis in breast cancer and its effect on serum type I carboxy terminal peptide( ICTP),osteocalcin( OSC),and osteoprotectin( OPG) The effect of urine type Ⅰ collagen pyridine cross-linked amino-terminal peptide( NTX). Methods Ninty-eight patients with bone metastases from advanced breast cancer admitted to the Liaoyou Baoshihua Hospital in Panjin from May 2015 to May 2017 were retrospectively selected as the research object. Forty-nine patients received NP regimen chemotherapy( NP group) and another 49 patients received NP regimen + pamidronate disodium treatment( combination group);compare the effects of chemotherapy,changes in serum ICTP,OSC,OPG,and urine NTX levels,two-year survival rate,and adverse reactions between the two groups. Results After treatment,the cure rate of patients in the combined group was24. 49%,the effective rate was 51. 02%,the effective rate was 16. 33%,and the inefficiency was 8. 16%. The cure rate of the NP group was14. 29%,the effective rate was 36. 73%,the effective rate was 32. 65%,and the inefficiency was 16. 33%,the curative effect of the combined group was better than that of the NP group,the difference was statistically significant( P < 0. 05). Before treatment,there was no significant difference in serum ICTP,OSC,OPG and urine NTX levels between the combination group and the NP group( P > 0. 05);after 2 months of treatment,the combined group’s ICTP,OSC,OPG urine NTX levels were( 3. 80 ± 0. 91) ng/mL,( 5. 84 ± 1. 26) ng/mL,( 9. 31 ± 1. 84) U/L,( 3. 73 ± 0. 77) nmol/L,which were lower than those in the NP group [( 4. 41 ± 1. 13) ng/mL,( 6. 60 ± 1. 34) ng/mL,( 10. 58 ± 2. 01) U/L,NTX( 4. 46 ± 0. 93) nmol/L],the differences were statistically significant( P < 0. 05). During the treatment,there was no statistical difference in the incidence of bone marrow suppression,nausea,vomiting,diarrhea,liver and kidney damage,and alopecia between the combine

关 键 词：乳腺癌 帕米膦酸二钠 NP方案 骨转移 

分 类 号：R737.9[医药卫生—肿瘤]