局部晚期食管-胃结合部腺癌的综合治疗进展  

Progress on integrated treatment of adenocarcinoma of esophagogastric junction

作　　者：吴嘉帝 黄炎 方彩燕 杨弘[1] WU Jiadi;HUANG Yan;FANG Caiyan;YANG Hong(Department of Thoracic Surgery,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangdong Esophageal Cancer Institute,Collaborative Innovation Center for Cancer Medicine,Guangzhou,510060,P.R.China)

机构地区：[1]中山大学肿瘤防治中心胸外科华南肿瘤学国家重点实验室广东省食管癌研究所肿瘤医学协同创新中心,广州510060

出　　处：《中国胸心血管外科临床杂志》2022年第2期251-256,共6页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81972614)。

摘　　要：外科手术是食管-胃结合部腺癌(adenocarcinoma of esophagogastric junction,AEG)的主要治疗手段,但是单纯手术对于局部晚期AEG的疗效不尽人意。为提高AEG的疗效,世界各地学者探究多种综合治疗模式对AEG的作用,包括新辅助化学治疗、新辅助放射治疗和化学治疗、围术期化学治疗、术后同期放射治疗和化学治疗等,其中术前放射治疗和化学治疗与围术期化学治疗备受研究者关注,两者均可改善局部晚期AEG的预后。然而,中国AEG综合治疗尚未被广泛关注,理念有待增强。为此,本文拟对以手术为主的AEG综合治疗模式的循证医学证据与研究进展做一综述。Surgery is an accepted standard in the treatment of adenocarcinoma of esophagogastric junction(AEG),but the efficacy of surgery alone for locally advanced AEG is limited.In-depth studies concerning combined therapy for AEG have been carried out worldwide,including neoadjuvant chemotherapy(nCT),neoadjuvant chemoradiotherapy(nCRT),perioperative chemotherapy(pCT),postoperative chemoradiotherapy,etc.Significantly,the contribution of nCRT and pCT to improving the prognosis of locally advanced AEG patients has been shed light on.Compared with that,multimodality treatment for AEG patients is not well established in China.An attempt was thus made to take an overview of the evidence-based research advance regarding integrated therapy of AEG.

关 键 词：食管-胃结合部腺癌 综合治疗模式 循证医学 综述 

分 类 号：R735.1[医药卫生—肿瘤] R735.2[医药卫生—临床医学]