Mitotic inactivation of the cGAS-MITA/STING pathways  

作　　者：Li Zhong Hong-Bing Shu 

机构地区：[1]Department of Infectious Diseases,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Research Unit of Innate Immune and Inflammatory Diseases of the Chinese Academy of Medical Sciences,Wuhan 430071,China

出　　处：《Journal of Molecular Cell Biology》2021年第10期721-727,共7页分子细胞生物学报（英文版）

基　　金：supported by grants from the National Key R&D Program of China(2017YFA0505800);the National Natural Science Foundation of China(31830024 and 31630045);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2019-I2M-5-071).

摘　　要：The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-mediator of interferon response factor 3 acti-vation/stimulator of interferon genes(MITA/STING)axis has emerged as a major pathway,which senses microbial or mislocated cellular DNA in the cytosol to trigger innate immune responses.cGAS senses cytosolic DNA without a preference of self-or nonself-DNA.How the cGAS-MITA/STING axis is inactivated upon nuclear envelope breakdown(NEBD)at mitotic entry in vertebrate cells to avoid self-DNA sensing remains unclear until very recently.In this review,we summarize the recent advances on how cGAS responds to chromosomes upon NEBD and the mechanisms involved in the inactivation of the cGAS-MITA/STING pathways in mitosis.

关 键 词：cGAS MITA STING MITOSIS innate immune response DNA 

分 类 号：Q55[生物学—生物化学]