不同临床特征IHH女性患者相关激素含量特征的风险  

Risk of different clinical characteristics associated with hormone content characteristics in women with IHH

作　　者：罗有文[1] 张忆聪[1] Luo Youwen;Zhang Yichong(Department of Clinical Laboratory,Maternal and Child Health Hospital of Guangdong Province,Gaozhou 511442,China)

机构地区：[1]广东省妇幼保健院医学检验科,广东高州511442

出　　处：《实用妇科内分泌电子杂志》2022年第1期23-26,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探究不同临床特征特发性低促性腺激素性性腺功能减退症(IHH)女性相关激素含量的特征。方法选取100例IHH女性患者为研究组,另选取同期68例健康女性为健康组。比较两组血清睾酮(T)、孕酮(P)、雌二醇(E2),25轻维生素D[25(OH)D]含量及研究组不同临床特征IHH女性患者T、P、E_(2),25(OH)D含量的差异。结果研究组T(1.80±0.23)nmol/L含量均高于健康组的(1.12±0.17)nmol/L,P(3.98±1.52)nmol/L、E_(2)(402.19±26.12)pmol/L、25(OH)D(25.64±5.80)nmol/L含量均明显低于健康组的(15.01±2.93)nmol/L、(238.11±11.06)pmol/L,(79.98±8.18)nmoVL,差异具有统计学意义(P<0.05)。研究组IHH女性患者不同典型临床表现、母亲孕期服药史、母亲孕期外伤史、母亲足月分娩、原发性闭经、身高指标中T、P、E_(2)、25(OH)D含量比较,差异具有统计学意义(P<0.05)。结论母亲孕期服药史、母亲孕期外伤史、母亲足月分娩、原发性闭经、身高均可明显影响IHH女性体内激素表达。Objective To explore the characteristics of honnone levels in different clinical characteristics of idiopathic hypogonadotropin hypogonadism(IHH).Methods 100 female patients with IHH were selected as the study group,and 68 healthy women were selected as the healthy group.The serum levels of testosterone(T),progesterone(P),estradiol(E_(2))and 25 hydroxyvitamin D[25(OH)D]were compared between the two groups and the levels of T,P,E_(2) and 25(OH)D in IHH patients with different clinical characteristics in the study group.Results The content of T(1.80±0.23)nmol/L in study group was higher than that in healthy group(1.12±0.17)nmol/L,P(3.98±1.52)nmol/L,E_(2)(402.19±26.12)pmol/L and 25(OH)D(25.64±5.80)nmol/L were significantly lower than those in healthy group(15.01±2.93)nmol/L and healthy group(238.11±11.06)pmol/L,(79.98±8.18)nmol/L,the difference was statistically significant(P<0.05).In the study group,there were statistically significant differences in typical clinical manifestations,mother's history of medication during pregnancy,mother's history of trauma during pregnancy,mother's term delivery,primary amenorrhea and T,P,E_(2) and 25(OH)D in height index of IHH female patients(PV0.O5).Conclusion Maternal history of medication during pregnancy,maternal history of trauma during pregnancy,maternal term delivery,primary amenorrhea and height can significantly afiect hormone expression in IHH women.

关 键 词：特发性低促性腺激素性性腺功能减退症 临床特征 激素表达 

分 类 号：R588[医药卫生—内分泌]