NGF治疗急性脑梗死的疗效及对血清VE-cadherin及MCP-1表达水平的影响  

Efficacy of NGF in the treatment of acute cerebral infarction and its influence on serum VE-cadherin and MCP-1 expression levels

作　　者：刘树东 郭耀华 LIU Shu-dong;GUO Yao-hua(The first department of Neurology,Wudi County People's Hospital,Binzhou 251900,China.)

机构地区：[1]无棣县人民医院神经内一科,山东滨州251900

出　　处：《中国处方药》2022年第1期96-98,共3页Journal of China Prescription Drug

摘　　要：目的探究注射用鼠神经生长因子(NGF)治疗急性脑梗死的疗效及对血清血管内皮钙黏蛋白(VE-cadherin)及单核细胞趋化因子(MCP-1)表达水平的影响。方法采取随机数表法对自2018年4月~2020年4月收治的急性脑梗死患者90例分组,各45例,对照组实施了常规抗血小板聚集、降低颅内压、稳定斑块、降脂、抗感染、维持水电平衡等基本治疗,观察组加用NGF,两组均连续治疗1个月。对比两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血清VE-cadherin及MCP-1表达水平,同时观察并记录治疗期间不良事件发生率。结果观察组与对照组相比临床总有效率较高,差异有统计学意义(P<0.05)。与对照组治疗后相比,观察组NIHSS评分较低,Barthel指数较高,血清VEcadherin及MCP-1表达水平均较低,差异有统计学意义(P<0.05)。两组不良事件发生率无明显差异(P>0.05)。结论在常规方法基础上加用NGF治疗急性脑梗死可有效改善患者的病情严重程度及神经功能,调节血清VE-cadherin及MCP-1表达水平,未增加不良事件风险,总体预后表现更好。Objective To explore the curative effect of injection of mouse nerve growth factor(NGF)in the treatment of acute cerebral infarction and the expression level of serum vascular endothelial cadherin(VE-cadherin)and monocyte chemotactic factor(MCP-1)Impact.Methods A random number table was used to divide 90 patients with acute cerebral infarction admitted to our hospital from April 2018 to April 2020,each with 45 cases.The control group was given routine basic treatments such as anti-platelet aggregation,lowering intracranial pressure,stabilizing plaque,lowering lipids,anti-infection,maintaining water and electricity balance,etc.The observation group was treated with NGF,and the two groups were treated for 1 month continuously.The efficacy of the two groups,the National Institutes of Health Stroke Scale(NIHSS)score,Barthel index,serum VE-cadherin and MCP-1 expression levels were compared between the two groups,and the incidence of adverse events during the treatment period was observed and recorded.Results Compared with the control group,the observation group had a higher clinical total effective rate,and the difference was statistically significant(P<0.05).Compared with the control group after treatment,the observation group had a lower NIHSS score,a higher Barthel index,and lower serum VE-cadherin and MCP-1 expression levels.The difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion The addition of NGF to the treatment of acute cerebral infarction on the basis of conventional methods can effectively improve the severity of the patient’s condition and neurological function,regulate the expression levels of serum VE-cadherin and MCP-1,without increasing the risk of adverse events,and the overall prognosis is better.

关 键 词：注射用鼠神经生长因子 急性脑梗死 疗效 神经功能 日常生活能力 血管内皮钙黏蛋白 单核细胞趋化因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]