化痰活血通络法治疗急性缺血性中风病的疗效观察  

Observation about the Therapeutic Effect of Resolving Phlegm,Activating Blood Circulation and Dredging Collaterals Methed on Acute Ischemic Stroke

作　　者：徐晖[1] 朱素有 张思迪 姚亮亮[1] XU Hui;ZHU Su-you;ZHANG Si-di;YAO Liang-liang(The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang330006)

机构地区：[1]江西中医药大学附属医院,南昌330006

出　　处：《实用中西医结合临床》2021年第24期4-7,共4页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省卫生和计划生育委员会中医药科研课题(编号:2018A006)。

摘　　要：目的:观察中药化痰活血通络法治疗急性缺血性中风病的疗效及对患者神经功能、血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)的影响。方法:选取2018年6月~2021年6月于急诊科、脑病科和ICU住院的100例痰瘀阻络型急性缺血性中风病患者作为研究对象,采用随机数字表法分为试验组和对照组,每组50例。对照组采用常规治疗,包括吸氧、监测生命体征、控制体温、抗血小板聚集、调脂、神经保护等,试验组在对照组基础上联合化痰活血通络中药治疗,两组疗程均为14 d。观察比较两组的临床疗效及治疗前后的神经功能缺损(NIHSS)评分、中文版巴氏指数量表(Barthel Index,BI)指数、SAA、CRP以及不良反应发生情况。结果:试验组总有效率为92%,显著高于对照组的72%(P<0.01)。治疗前,两组NIHSS评分、BI指数及血清SAA、CRP比较均无显著差异(P>0.05);治疗后,两组NIHSS评分及血清SAA、CRP均显著下降,且试验组NIHSS评分及CRP显著低于对照组(P<0.01),两组SAA比较无显著差异(P>0.05);两组BI指数较前均显著提高,试验组显著高于对照组(P<0.01);试验组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论:联合中药化痰活血通络法治疗痰瘀阻络型急性缺血性中风病可以获得更显著的疗效,更大程度地改善患者神经功能、提高日常生活能力及降低患者血清SAA、CRP水平,且临床安全性高。Objective:To observe the therapeutic effect of resolving phlegm,activating blood circulation and dredging collaterals methed on acute ischemic stroke and its effects on neurological function,serum amyloid A(SAA),C-reactive protein(CRP).Methods:From June 2018 to June 2021,100 patients with acute ischemic stroke of phlegm and blood stasis blocking collaterals hospitalized in emergency department,encephalopathy department and ICU were selected as the research objects.They were randomly divided into experimental group and control group,with 50 cases in each group.The control group was treated with routine treatment,including oxygen inhalation,monitoring vital signs,controlling body temperature,anti platelet aggregation,lipid regulation and neuroprotection.The experimental group was treated with traditional Chinese medicine for resolving phlegm,activating blood circulation and dredging collaterals on the basis of the control group.The course of treatment of both groups was 14 days.The clinical efficacy,NIH Stroke Scale(NIHSS)score,Barthel Index(BI),SAA,CRP and adverse reactions were observed and compared between the two groups before and after treatment.Results:The total effective rate in the experimental group was 92%,which was significantly higher than 72%in the control group(P<0.01).Before treatment,there was no significant difference in NIHSS score,BI index,serum SAA and CRP between the two groups(P>0.05);After treatment,NIHSS score,serum SAA and CRP in the two groups decreased significantly,and NIHSS score and CRP in the experimental group were significantly lower than those in the control group(P<0.01).There was no significant difference in SAA between the two groups(P>0.05);The BI index of the experimental group was significantly higher than that of the control group(P<0.01);The incidence of adverse reactions in the experimental group was lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Combined with traditional Chinese medicine to resolve phlegm,activ

关 键 词：急性缺血性中风病 化痰活血通络法 SAA CRP 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]