Ultrastructural alterations of megakaryocytes in thrombocytopenia:A review of 43 cases  

作　　者：Brian Eyden Yong-Xin Ru Shu-Xu Dong Jing Liu Xiao-Fan Liu 

机构地区：[1]Department of Histopathology,Christie NHS Foundation Trust,Manchester,UK [2]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,China

出　　处：《Blood Science》2021年第4期107-112,共6页血液科学（英文）

摘　　要：Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases;however,the details of the mechanism leading to low platelet count remain elusive.Megakaryocytes are a series of progenitor cells responsible for the production of platelets.Alterations in megakaryocytes in the bone marrow are a causative factor resulting in thrombocytopenia in varied diseases.Based on ultrastructural analysis of incidentally encountered megakaryocytes in 43 patients with blood diseases marked by low platelet counts,electron micrographs demonstrated that aberrant megakaryocytes predominated in idiopathic thrombocytopenic purpura,aplastic anemia,and myelodysplastic syndrome;autophagy,apoptosis,and cellular damage in megakaryocytes were a prominent feature in aplastic anemia.On the other hand,poorly differentiated megakaryocytes predominated in acute megakaryoblastic leukemia(AMKL)although damaged megakaryocytes were seen in non-AMKL acute leukemia.This paper documents the ultrastructural alterations of megakaryocytes associated with thrombocytopenia and reveals distinctive features for particular blood diseases.A comment is made on future avenues of research emphasizing membrane fusion proteins.

关 键 词：Blood disease MEGAKARYOCYTE PLATELET THROMBOCYTOPENIA ULTRASTRUCTURE 

分 类 号：R55[医药卫生—血液循环系统疾病]