Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application  

作　　者：Li-Min Lin Qi Pan Yu-Meng Sun Wen-Tao Wang 

机构地区：[1]MOE Key Laboratory of Gene Function and Regulation,State Key Laboratory for Biocontrol,School of Life Sciences,Sun YatSen University,Guangzhou,Guangdong 510275,China

出　　处：《Blood Science》2021年第4期122-131,共10页血液科学（英文）

基　　金：National Natural Science Foundation of China(82000168 and 31870818)。

摘　　要：Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis,prognosis,and treatment of leukemia.Research has found that small nuclear RNA(snoRNA)plays an essential role in leukemia.These small non-coding RNAs are involved in ribosome biogenesis,including the 2'-O-methylation and pseudouridylation of precursor ribosomal RNA(pre-rRNA),and pre-rRNA splicing.Recently,many snoRNAs were found to be orphans that have no predictable RNA modification targets,but these RNAs have always been found to be located in different subcellular organelles,and they play diverse roles.Using high-throughput technology,snoRNA expression profiles have been revealed in leukemia,and some of the deregulated snoRNAs may regulate the cell cycle,differentiation,proliferation,and apoptosis in leukemic cells and confer drug resistance during leukemia treatment.In this review,we discuss the expression profiles and functions of snoRNAs,particularly orphan snoRNAs,in leukemia.It is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia,which may serve as potential therapeutic targets in leukemia treatment.

关 键 词：2'-O-methylation Biomarkers Drug resistance LEUKEMIA SNORNA Targeted therapy 

分 类 号：R73[医药卫生—肿瘤]