Integrin α_(v)β_(3)-targeted polydopamine-coated gold nanostars for photothermal ablation therapy of hepatocellular carcinoma  

作　　者：Yang Li Ping Hu Xiali Wang Xu Hou Fengzhen Liu Xiaohong Jiang 

机构地区：[1]Zhong Yuan Academy of Biological Medicine,Liaocheng People’s Hospital,No.67 Dongchang West Road,Liaocheng 252000,China [2]Clinical Laboratory,Liaocheng People’s Hospital,No.67 Dongchang West Road,Liaocheng 252000,China [3]Department of Hepatobiliary Surgery,Liaocheng People’s Hospital,No.67 Dongchang West Road,Liaocheng 252000,China [4]Liaocheng People’s Hospital,Medical College of Liaocheng University,No.67 Dongchang West Road,Liaocheng 252000,China [5]School of Basic Medical Sciences,Shandong University,No.44 Wenhua West Road,Jinan 250012,China

出　　处：《Regenerative Biomaterials》2021年第5期134-147,共14页再生生物材料（英文版）

基　　金：support from National Natural Science Foundation of China(NSFC81602736);China Postdoctoral Science Foundation(2018M632684);Shandong Provincial Natural Science Foundation(ZR2019PH084);Liaocheng People’s Hospital Youth Research Fund(LYQN201935).

摘　　要：Photothermal therapy(PTT)has emerged as a promising cancer therapeutic method.In this study,Arg-Gly-Asp(RGD)peptide-conjugated polydopamine-coated gold nanostars(Au@PDA-RGD NPs)were prepared for targeting PTT of hepatocellular carcinoma(HCC).A polydopamine(PDA)shell was coated on the surface of gold nanostars by the oxidative self-polymerization of dopamine(termed as Au@PDA NPs).Au@PDA NPs were further functionalized with polyethylene glycol and RGD peptide to improve biocompatibility as well as selectivity toward the HCC cells.Au@PDARGD NPs showed an intense absorption at 822 nm,which makes them suitable for near-infraredexcited PTT.Our results indicated that the Au@PDA-RGD NPs were effective for the PTT therapy of the α_(v)β_(3) integrin receptor-overexpressed HepG2 cells in vitro.Further antitumor mechanism studies showed that the Au@PDA-RGD NPs-based PTT induced human liver cancer cells death via the mitochondrial-lysosomal and autophagy pathways.In vivo experiments showed that Au@PDARGD NPs had excellent tumor treatment efficiency and negligible side effects.Thus,our study showed that Au@PDA-RGD NPs could offer an excellent nanoplatform for PTT of HCC.

关 键 词：polydopamine-coated gold nanostars RGD peptide targeted photothermal therapy hepatocellular carcinoma 

分 类 号：R735.7[医药卫生—肿瘤] R318.08[医药卫生—临床医学]