NLRP3炎症小体在年龄相关性黄斑变性中的作用  

NLRP3 inflammasome and its role in age-related macular degeneration

作　　者：陈露(综述) 谢平[1] 胡仔仲(审校) Chen Lu;Xie Ping;Hu Zizhong(Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Ophthalmology,The Affiliated Xuzhou First People's Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]南京医科大学第一附属医院眼科,210029 [2]徐州医科大学附属徐州市第一人民医院眼科,221002

出　　处：《中华实验眼科杂志》2022年第1期73-77,共5页Chinese Journal Of Experimental Ophthalmology

摘　　要：年龄相关性黄斑变性(AMD)是引起全球50岁以上老年人中心视力损害的主要原因,也是全世界主要的致盲眼病之一。临床上将进展期AMD分为萎缩性AMD和渗出性AMD,分别表现为脉络膜地图样萎缩和新生血管形成。AMD的发病机制复杂,其中炎症反应起重要作用。核苷酸结合寡聚化结构域样受体3(NLRP3)炎症小体是一种细胞质内模式识别受体,在视网膜色素上皮(RPE)细胞、小胶质细胞、Müller细胞、血管内皮细胞等中均有表达。最近的研究表明,NLRP3炎症小体与AMD疾病相关,并参与渗出性AMD和萎缩性AMD的发生。本文对NLRP3炎症小体及其下游因子白细胞介素(IL)-1β和IL-18在AMD发病和治疗中的作用进行综述,为探讨AMD的发病机制和治疗策略提供新的思路。Age-related macular degeneration(AMD),the leading cause of central vision loss among people aged 50 years and older,is one of the major eye diseases causing blindness in the world.Clinically,advanced AMD is divided into two types,non-exudative AMD with manifestation of geographic atrophy and exudative AMD with manifestation of choroidal neovascularization.The pathogenesis of AMD is complex,and the para-inflammation is recognized as an important risk factor.Nucleotide-binding oligomerization domain like receptors 3(NLRP3)inflammasome is a cytoplasmic pattern recognition receptor and is expressed in several kings of cells,including retinal pigment epithelium(RPE)cells,microglial cells,Müller glia cells and retinal vascular endothelial cells.Recent studies have suggested that NLRP3 inflammasome plays an important role in the pathophysiology of both non-exudative and exudative AMD.The role of the NLRP3 inflammasome and its effector cytokines interleukin(IL)-1βand IL-18 in AMD were reviewed in this article to provide guidance on future prevention and therapy of AMD.

关 键 词：黄斑变性 炎症小体 核苷酸结合寡聚化结构域样受体3 视网膜色素上皮细胞 白细胞介素18 白细胞介素1Β 

分 类 号：R774.5[医药卫生—眼科]