精神分裂症动物模型发病机制研究  

Research on Pathogenesis of Animal Models of Schizophrenia

作　　者：李永丰 陈帅 乔海法 杨晓航 LI Yongfeng;CHEN Shuai;QIAO Haifa;YANG Xiaohang(Innovation Center for Combination of Acupuncture and Medicine,College of Acupuncture and Massage,Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学针灸推拿学院针药结合创新中心,陕西咸阳712046

出　　处：《现代中医药》2022年第1期1-9,共9页Modern Chinese Medicine

基　　金：国家自然科学基金青年项目(82004489);陕西省教育厅项目(20JK0592)。

摘　　要：精神分裂症患者的发病机制病理生理机制研究还不够深入,对不同研究和动物模型的核心是神经环路障碍,其包括兴奋和抑制之间的稳态失调,突触可塑性功能的改变,神经元局部和投射环路的改变,受体表达水平的变化及基因的改变;主要表现为多巴胺神经元功能的适应性改变。The research on the pathogenesis and pathophysiological mechanism of schizophrenic patients is not deep enough.The core of different studies and animal models is neural circuit disorder,which includes the imbalance between excitation and inhibition,the change of synaptic plasticity function,the change of neuronal local and projection circuit,the change of receptor expression level and gene change;It is mainly manifested in the adaptive changes of dopamine neuron function.

关 键 词：精神分裂症 神经环路 动物模型 生理功能 突触可塑性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]