取代苯酚的高效溴化体系探究  

Study on Efficient Bromination System of Substituted Phenol

作　　者：凌佳楠 陈婕妤 高明明 王满菊 李军[1] 杜文婷[1] LING Jia-nan;CHEN Jie-yu;GAO Ming-ming;WANG Man-ju;LI Jun;DU Wen-ting(Hangzhou Medical College,Hangzhou,Zhejiang 310053,China)

机构地区：[1]杭州医学院,浙江杭州310053

出　　处：《浙江化工》2022年第1期14-18,共5页Zhejiang Chemical Industry

基　　金：浙江省自然科学基金/探索项目(LY21H300003);国家级大学生创新创业训练计划(202113023007)。

摘　　要：溴酚类化合物作为中间体在抗肿瘤、抗细菌、抗真菌、抗病毒及抗氧剂等方面广泛运用,备受关注。但传统溴代试剂存在许多不足,如强腐蚀性、污染环境、价格昂贵、溴利用率低,不利于工业生产等。本文以苯酚为底物、溴化盐为溴化剂,对酚类化合物进行溴化,筛选溴化盐、催化剂的类型和用量、反应溶剂的类型和用量、反应温度等,探究影响反应转化率和化学选择性的关键因素,优化反应条件以形成高效、环境相对友好、选择性可控的反应体系,并拓展底物。将最佳反应体系应用于各种类型酚,考察反应体系的适用性。通过对溴代产物的气相分析,发现该方法适用于多数酚类溴代反应,且具有绿色安全、高选择性和溴利用率高等优点,是一种新型的酚类溴代方法。Bromophenolic compounds are widely used as intermediates in anti-tumor, anti-bacterial, antifungal, anti-virus and antioxidants, and have attracted much attention. However, traditional bromination reagents have many shortcomings, such as strong corrosiveness, environmental pollution, high price, and low bromine utilization rate, which is not conducive to industrial production. In this paper, phenol is used as substrate and bromide salt is used as brominating agent to brominate phenolic compounds. The type and amount of bromide salt, catalyst, type and amount of reaction solvent, reaction temperature, etc. are screened to explore the influence of reaction conversion rate. And the key factor of chemoselectivity, optimize the reaction conditions to form an efficient, relatively environmentally friendly, selectivity controllable reaction system, and expand the substrate.The optimum reaction system was applied to various types of phenols, and the applicability of the reaction system was investigated. Through the gas phase analysis of the brominated products, it is found that this method is suitable for most phenolic bromination reactions, and has the advantages of green safety, high selectivity and high bromine utilization rate. It is a new phenolic bromination method.

关 键 词：酚类化合物 溴化 环境友好 

分 类 号：TQ243.3[化学工程—有机化工]