基于多波长光电容积脉搏波采集系统的连续血压测量方法  

Continuous blood pressure measurement method based on multi-wavelength photoplethysmography acquisition system

作　　者：李嘉玮 张劲[1] 白中博 黄德青 LI Jiawei;ZHANG Jing;BAI Zhongbo;HUANG Deqing(Department of Medical Information Engineering,Sichuan University.,Chengdu Sichuan 610065,China;Analog Devices Incorporation,Beijing 100192,China;Department of Electronic Information Engineering,Southwest Jiaotong University,Chengdu Sichuan 611756,China)

机构地区：[1]四川大学医学信息工程系,成都610065 [2]亚德诺半导体技术有限公司,北京100192 [3]西南交通大学电子信息工程系,成都611756

出　　处：《计算机应用》2021年第S02期351-356,共6页journal of Computer Applications

基　　金：国家自然科学基金资助项目(61571314);四川省科技厅项目(2020YFG0081)。

摘　　要：为解决目前在国内外高血压诊断中难以实现连续血压监测的问题,在现有光电容积脉搏波测量血压的研究基础上,提出了一种基于多波长的光电容积脉搏波监测血压的方法。首先,基于不同波长的光穿透能力不同的理论,以红外、蓝、黄、绿四种波长光LED阵列结合光电接收管构成采集前端,收集人体皮下不同层的脉搏原始信号,经过微处理器采样后在上位机保存和处理;然后,使用数字滤波的方式和一阶微分的方法对信号作去噪处理和比较得到不同波长的光对应的光电容积信号之间的传导时间差信息,由脉搏波与血压的关系得到多波长光电信号传导时间差与血压的关系;最后,设计实验得到30例被测者的多波长脉搏波信号,将从信号中得到的传导时间差结合心率与标准电子血压计测量计算的平均血压值结果做拟合得到R值为-0.833 03的拟合曲线。对30例样本的舒张压及收缩压进行了预测,其中收缩压预测值与实际值之间的R值为0.932 2,舒张压预测值与实际值之间的R值为0.846 8。实验结果表明,由多波长光电容积法信号之间得到的传导时间差信息与血压有相关关系,可以用多波长光电容积信号的传导时间差作为传统光电容积法脉搏传导时间的替代,但由于样本特征的局限性仍然在个体的差异性诸如肤色等特征研究上存在不足。与主流的无袖带血压测量方式相比,基于多波长光电容积法测量血压连续性好、便携性高,在可穿戴生理参数测量设备中具有广阔的应用前景。Concerning the difficulty of continuous blood pressure monitoring in the diagnosis of hypertension at home and abroad,considering the existing research of photoplethysmography to measure blood pressure,a method based on multiwavelength photoplethysmography to monitor blood pressure was introduced. Firstly,according to the theory of different wavelengths of light having different penetration capabilities,the LED arrays with four wavelengths(infrared,blue,yellow,green)and two photodiodes were selected to form the collection front end to collect the raw pulse signals of different layers of the skin. These signals were sampled by the microprocessor and stored and processed in the host computer. Secondly,the methods of digital filtering and first-order differentiation were selected to denoise the signal and compare to obtain the transit time difference information between the photoplethysmography signals with different wavelengths. The relationship between the transit time difference and blood pressure was obtained from the relationship between pulse wave and blood pressure.Finally,the multi-wavelength photoplethysmography signals of 30 subjects were obtained by the experiment,and then the transit time difference and heart rate obtained from the signals were combined with the mean blood pressure which were measured and calculated by a standard electronic sphygmomanometer to obtain a fitting curve with R value of-0. 833 03.The diastolic and systolic blood pressures of 30 subjects were predicted. The R value between the predicted and actual systolic blood pressures was 0. 932 2,and the R value between the predicted and actual diastolic blood pressures was0. 846 8. The experimental results show that,the transit time difference information obtained from the multi-wavelength photoplethysmography signals is related to blood pressure,and the transit time difference of the multi-wavelength photoplethysmography signals can be used as a substitute for the pulse transit time of the traditional photoplethysmography method. Howeve

关 键 词：脉搏波 血压 光电容积脉搏波 信号处理 可穿戴设备 

分 类 号：TN911.7[电子电信—通信与信息系统] R318.6[电子电信—信息与通信工程]