热应激对鱼类hsp70基因和caspase-3基因影响的研究进展  

Research progress of heat stress on gene hsp70 and caspase-3 in fish

作　　者：张华琨 王冠 王秀利 ZHANG Hua-kun;WANG Guan;WANG Xiu-li(College of Fisheries and Life Science,Dalian Ocean University,Dalian 116023,China)

机构地区：[1]大连海洋大学水产与生命学院,辽宁大连116023

出　　处：《河北渔业》2022年第2期28-32,共5页

基　　金：财政部和农业农村部:国家现代农业产业技术体系资助(CARS-47)。

摘　　要：鱼类对温度的适应因其种类不同而有差异,这是长期进化和演变的结果。本文通过对不同种鱼类的最大临界温度和高起始致死温度这两个热耐受性指标、耐热相关基因的表达等进行了综述,发现影响鱼类耐热能力的重要因素是基础水温和温度升高的速率,以及生物的生理及遗传,进而掌握不同鱼类的耐热能力,并对在高温胁迫下表达差异显著的hsp70基因和caspase-3细胞凋亡相关基因进行了分析讨论;发现热应激使hsp70在鱼类体内的合成速度显著增加,以提高鱼类的抗应激能力,同时也会使caspase-3基因被激活,诱导细胞发生凋亡。The adaptation of fish to temperature varies depending on their species as a result of long-term evolution and evolution.In this article two heat tolerance indices-the upper critical temperature and the initial high lethal temperature,as well as heat resistance related gene expression of different kinds of fish were summarized.And it was found that the important factors affecting the thermal tolerance of fish are the basal water temperature and the rate of temperature increase,as well as the physiology and genetics of the organisms,and then the thermal tolerance of different fish was grasped,gene hsp70 and caspase-3 apoptosis-related genes that were significantly differentially expressed under high temperature stress were analyzed and discussed,it was found that heat stress caused a significant increase in the rate of hsp70 synthesis in fish to improve their stress resistance,and also caused gene caspase-3 to be activated and induced apoptosis.

关 键 词：鱼类 热耐受性 HSP70基因 CASPASE-3基因 

分 类 号：R73[医药卫生—肿瘤]