乳腺癌原发灶与转移灶内雌激素受体及孕激素受体水平变化分析  

Changes of estrogen receptor and progesterone receptor levels in primary and metastatic breast cancer

作　　者：孙铁 王英姿[1] 李立[1] SUN Tie;WANG Ying-zi;LI Li(Department of General Surgery,Liaoning Provincial People’s Hospital,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院普外三科,110016

出　　处：《中国实用医药》2022年第2期14-16,共3页China Practical Medicine

摘　　要：目的分析乳腺癌原发灶与转移灶内雌激素受体(ER)及孕激素受体(PR)水平变化的临床意义。方法82例存在远处转移灶或腋窝淋巴结转移灶的乳腺癌患者,其中远端转移灶患者40例,腋窝淋巴结转移灶患者42例。切除患者局部组织,获取乳腺癌原发灶及转移灶组织,采用免疫组织化学(免疫组化)方法检测病灶中ER、PR水平。分析比较原发灶与转移灶中ER、ER的表达差异,并根据ER、PR表达的不同情况调整治疗方案,观察治疗情况。结果腋窝淋巴结转移灶患者ER、PR检测结果显示,原发灶阳性率分别为76.2%、71.4%,腋窝淋巴结转移灶阳性率为73.8%、52.4%,腋窝淋巴结转移灶和原发灶表达不一致率分别为7.1%、14.3%。远处转移灶患者中ER、PR检测结果显示,原发灶阳性率分别为75.0%、27.5%,远处灶阳性率分别为72.5%、50.0%,远处转移灶和原发灶中不一致率分别为22.5%、27.5%。腋窝淋巴结转移灶与原发灶ER表达率比较,差异无统计学意义(χ^(2)=0.063,P>0.05)。腋窝淋巴结转移灶与原发灶PR的表达率比较,差异无统计学意义(χ^(2)=3.231,P>0.05)。远处转移灶与原发灶ER表达率比较,差异无统计学意义(χ^(2)=0.065,P>0.05)。远处转移灶与原发灶PR表达率比较,差异有统计学意义(χ^(2)=4.270,P<0.05)。根据乳腺癌患者受体表达情况,有22.0%(18/82)的患者应增加内分泌治疗。结论乳腺癌患者体内原发灶与转移灶ER、PR的表达存在一定差异,临床治疗过程中应对患者体内病灶进行受体再检查,依据原发灶及转移灶激素受体的表达对患者进行治疗。Objective To analyze the clinical significance of changes of estrogen receptor(ER)and progesterone receptor(PR)levels in primary and metastatic breast cancer.Methods There were 82 breast cancer patients with distant metastases or axillary lymph node metastases,including 40 patients with distant metastases,and 42 patients with axillary lymph node metastases.The local tissues of the patients were resected to obtain the primary breast cancer and metastatic tissues,and immunohistochemical methods were used to detect the levels of ER and PR in the lesions.The expression difference of ER and ER in the primary breast cancer and metastases were analyzed.The treatment plan was adjusted according to the different expression of ER and PR,and their treatment situation was observed.Results The results of ER and PR tests in patients with axillary lymph node metastases showed that the positive rates of primary tumor were 76.2%and 71.4%,and the positive rates of axillary lymph node metastases were 73.8%and 52.4%,with an inconsistent expression rates of axillary lymph node metastases and primary tumor of 7.1%and 14.3%.The results of ER and PR tests in patients with distant metastases showed that the positive rates of primary tumors were 75.0%and 27.5%,and the positive rates of distant tumors were 72.5%and 50.0%,with an inconsistent expression rates of distant metastases and primary tumors of 22.5%and 27.5%.There was no statistically significant difference in the expression rate of ER between axillary lymph node metastases and primary tumors(χ^(2)=0.063,P>0.05).There was no statistically significant difference in the expression rate of PR between axillary lymph node metastases and primary tumors(χ^(2)=3.231,P>0.05).There was no statistically significant difference in the expression rate of ER between distant metastases and primary tumors(χ^(2)=0.065,P>0.05).The difference in the PR expression rate between distant metastases and primary tumors was statistically significant(χ^(2)=4.270,P<0.05).Based on receptor expression in bre

关 键 词：乳腺癌 原发灶 转移灶 雌激素受体 孕激素受体 

分 类 号：R737.9[医药卫生—肿瘤]