非小细胞肺癌组织驱动蛋白超家族成员2A、真核起始因子3b的mRNA表达及其临床意义  

Expressions and clinical significance of kinesin family member 2A,eukaryotic initiation factor 3b mRNA in non-small cell lung cancer tissues

作　　者：邴钟兴[1] 郑志博 张家齐[1] BING Zhongxing;ZHENG Zhibo;ZHANG Jiaqi(Department of Thoracic Surgery,Peking Union Medical College Hospital,Beijing 100005,China)

机构地区：[1]北京协和医院胸外科,100005

出　　处：《临床外科杂志》2021年第12期1123-1126,共4页Journal of Clinical Surgery

基　　金：2015年度北京市科技发展指导性计划(BJSW2015011)。

摘　　要：目的探讨非小细胞肺癌(NSCLC)组织中驱动蛋白超家族成员2A(KIF2A)、真核起始因子3b(eIF3b)mRNA表达与病人临床病理特征及预后的关系。方法收集NSCLC病人组织样本,检测KIF2A、eIF3b mRNA表达并分析其与病人临床病理特征的关系,Pearson法分析癌组织KIF2A与eIF3b mRNA表达的相关性,Kaplan-Meier生存曲线分析KIF2A、eIF3b mRNA表达与病人预后的关系,Cox回归模型分析病人的预后影响因素。结果NSCLC癌组织中,KIF2A mRNA、eIF3b mRNA相对表达水平高于癌旁正常组织(P<0.05);KIF2A mRNA表达与分化程度、淋巴结转移及临床分期相关,eIF3b mRNA表达与肿瘤大小、淋巴结转移及临床分期相关(P<0.05)。Pearson法分析结果显示,NSCLC癌组织KIF2A mRNA与eIF3b mRNA表达呈正相关(P<0.05)。Kaplan-Meier生存曲线结果显示,KIF2A高表达组、eIF3b高表达组的预后较差(P<0.05)。Cox回归模型分析结果显示,临床分期为Ⅲ期、KIF2A mRNA高表达、eIF3b mRNA高表达是病人预后的独立危险因素(P<0.05)。结论NSCLC癌组织中KIF2A mRNA、eIF3b mRNA高表达,两者均参与NSCLC发生发展,有望成为疾病进展及预后评估的新的生物学靶点。Objective To explore the relationships between kinesin family member 2 A(KIF2 A),eukaryotic initiation factor 3 b(eIF3 b)mRNA expressions in non-small cell lung cancer(NSCLC)cancer tissues to clinicopathological characteristics and prognosis.Methods The tissue samples from NSCLC patients were collected,the expression of KIF2 A and eIF3 b mRNA were detected and their relationship with clinicopathological characteristics were analyzed.Pearson was used to analyze the correlation between KIF2 A and eIF3 b mRNA expression in cancer tissues.The Kaplan-Meier survival curve was used to analyze the relationship of KIF2 A,eIF3 b mRNA expression with the prognosis of patients.The Cox regression model was used to analyze the influence factors of prognosis of patients.Results In the NSCLC cancer tissues,the KIF2 A mRNA,eIF3 b mRNA expression levels were higher than those in adjacent normal tissues(P<0.05).The KIF2 A mRNA expression was related with differential degree,lymph node metastasis and clinical stages,while the eIF3 b mRNA expression was related with tumor size,lymph node metastasis and clinical stages(P<0.05).The Pearson results showed that there was a positive relationship between the KIF2 A mRNA expression and eIF3 b mRNA expression(P<0.05).Kaplan-Meier survival curve results showed that patients with high KIF2 A mRNA expression and eIF3 b mRNA expression had poor prognosis(all P<0.05).Cox regression model analysis results showed that,clinical stage wasⅢstage,high KIF2 A mRNA expression and high eIF3 b mRNA expression were the risk factors for the prognosis of NSCLC(P<0.05).Conclusions KIF2 A mRNA and eIF3 b mRNA are highly expressed in NSCLC cancer tissues.Both of them are involved in the occurrence and development of NSCLC,and they are expected to become new biological targets for disease progression and prognosis evaluation.

关 键 词：非小细胞肺癌 KIF2A eIF3b 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]