From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine  

作　　者：Niels G.A.Willemen Margaretha A.J.Morsink Devin Veerman Classius F.da Silva Juliana C.Cardoso Eliana B.Souto Patrícia Severino 

机构地区：[1]Center for Biomedical Engineering,Department of Medicine,Brigham and Women&Hospital,Harvard Medical School,65 Landsdowne Street,MA 02139 Cambridge,USA [2]Department of Developmental BioEngineering,Faculty of Science and Technology,Technical Medical Centre,University of Twente,Enschede,The Netherlands [3]Translational Liver Research,Department of Medical Cell BioPhysics,Technical Medical Centre,Faculty of Science and Technology,University of Twente,Enschede,The Netherlands [4]Targeted Therapeutics,Department of Biomaterials Science and Technology,Faculty of Science and Technology,University of Twente,Enschede,The Netherlands [5]Department of Chemical Engineering,Institute of Environmental,Chemical and Pharmaceutical Sciences,Federal University of São Paulo,Rua São Nicolau,210,Diadema 09913‑030,Brazil [6]University of Tiradentes(Unit),and Institute of Technology and Research(ITP),Av.Murilo Dantas,300,Aracaju 49010‑390,Brazil [7]Faculty of Pharmacy,University of Coimbra,Pólo das Ciências da Saúde,Azinhaga de Santa Comba,3000‑548 Coimbra,Portugal [8]CEB‑Centre of Biological Engineering,University of Minho,Campus de Gualtar,4710‑057 Braga,Portugal [9]Tiradentes Institute,150 Mt Vernon St,Dorchester,MA 02125,USA

出　　处：《Bio-Design and Manufacturing》2022年第1期85-106,共22页生物设计与制造（英文）

摘　　要：Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关 键 词：Drug delivery systems 3D/4D printing Drug-eluting implants MICRONEEDLES Oral formulations 

分 类 号：R943[医药卫生—药剂学]