次氯酸钠和洗必泰作为牙根管消毒冲洗液对根管内的感染物质的影响  

Effects of Sodium Hypochlorite and Chlorhexidine as Root Canal Disinfection Rinsing Solution on Oral Flora and Infective Substances in Root Canals

作　　者：王小勤 薛云鹏 柴雪 赵广宁 张斌[2] WANG Xiao-qin;XUE Yun-peng;CHAI Xue;ZHAO Guang-ning;ZHANG Bin(Department of Endodontics,Hospital of Stomatology,Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China;Department of Preventive Health,Hospital of Stomatology,Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China)

机构地区：[1]西安交通大学口腔医院牙体牙髓病科,陕西西安710004 [2]西安交通大学口腔医院预防保健科,陕西西安710004

出　　处：《现代生物医学进展》2021年第23期4487-4491,共5页Progress in Modern Biomedicine

基　　金：陕西省卫生健康委科研项目(2021E020)。

摘　　要：目的:探究次氯酸钠和洗必泰作为牙根管消毒冲洗液的对根管内感染物质的影响。方法:选取76例接受根管治疗的患者根据随机数字表法分为观察组和对照组2组,其中对照组患者采用次氯酸钠治疗,观察组患者则采用次氯酸钠和洗必泰联合治疗。对比分析两组患者根管内细菌菌落计数、根管内感染物质、治疗效果、远期有效率和不良反应发生率。结果:根管消毒冲洗后观察组根管内细菌菌落计数和根管内感染物质显著低于对照组,差异具有统计学意义(P<0.05);观察组患者治疗总有效率和不良反应的发生率分别为100.00%和13.16%,对照组患者治疗总有效率和不良反应的发生率分别为88.00%和65.79%,差异具有统计学意义(P<0.05)。另外,观察组患者第3个月、第6个月和1年后的治疗有效率均大于对照组。结论:次氯酸钠和洗必泰作为牙根管消毒冲洗液能够有效的减少根管内的感染物质的数量,提高治疗有效率,降低不良反应的发生率,值得临床推广使用。Objective:To investigate the effects of sodium hypochlorite and chlorhexidine as root canal disinfection rinsing solution on oral flora and root canal infection substances.Methods:Seventy-six patients who received root canal treatment were divided into observation group and control group according to the random number table method,in which the control group was treated with sodium hypochlorite and the observation group was treated with sodium hypochlorite and chlorhexidine combined.The detection rate of oral flora,bacterial colony count in the root canal,infectious substances in the root canal,therapeutic effect,long-term effective rate and incidence of adverse reactions in two groups were compared and analyzed.Results:After root canal disinfection and irrigation,the bacterial colony count and root canal infection substances in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).The incidence of total effective rate and adverse reaction in the observation group was100.00%and 13.16%,respectively,and the incidence of total effective rate and adverse reaction in the control group was 88.00%and65.79%,respectively(P<0.05).In addition,the effective rate of observation group was higher than control group at 3 months,6 months and 1 year later.Conclusion:Sodium hypochlorite and chlorhexidine,as root canal disinfection rinsing solutions,can effectively reduce the number of oral flora and infectious substances in the root canal,improve the treatment efficiency and reduce the incidence of adverse reactions.Therefore,they are worthy of widespread clinical use.

关 键 词：次氯酸钠 洗必泰 牙根管 口腔菌群 感染物质 

分 类 号：R781.3[医药卫生—口腔医学] R988.2[医药卫生—临床医学]