肿瘤相关中性粒细胞在结直肠癌中的研究进展  

Progress of tumor⁃associated neutrophils in colorectal cancer

作　　者：李童恺 郭建昇[1] Li Tongkai;Guo Jiansheng(Department of General Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院普外科,太原030001

出　　处：《肿瘤研究与临床》2021年第11期874-877,共4页Cancer Research and Clinic

摘　　要：结直肠癌是世界范围内导致癌症死亡的最常见原因之一,近年来结直肠癌患者的数量逐步增加。已证明炎症在癌症的发生、发展中起着特殊的作用,中性粒细胞作为重要的炎症细胞,其在肿瘤中的作用也逐渐成为研究热点。已发现肿瘤相关中性粒细胞在肿瘤微环境中可以被极化为促肿瘤和抗肿瘤两种表型,并具有促进血管生成以及肿瘤细胞远处迁移的能力。文章综述了肿瘤相关中性粒细胞在结直肠癌发生、发展与转移中的作用,以及肿瘤相关中性粒细胞作为癌症治疗潜在靶点的可能性。Colorectal cancer is one of the most common causes of cancer death worldwide.In recent years,the number of patients with colorectal cancer has gradually increased.It has been proved that inflammation plays a special role in the occurrence and development of cancer.As important inflammatory cells,the role of neutrophils in tumors has gradually become research hotspots.It has been found that tumor⁃associated neutrophils can be polarized into pro⁃tumor and anti⁃tumor phenotypes in the tumor microenvironment,and have the ability to promote angiogenesis and tumor cell migration.This article reviews the role of tumor⁃associated neutrophils in the occurrence,development and metastasis of colorectal cancer,and the possibility of tumor⁃associated neutrophils as potential targets for cancer treatment.

关 键 词：结直肠肿瘤 肿瘤相关中性粒细胞 肿瘤微环境 放射疗法 

分 类 号：R735.34[医药卫生—肿瘤]