白细胞介素6和信号转导及转录激活因子3信号通路在结直肠癌中的研究进展  

Progress of interleukin⁃6 and signal transducer and activator of transcription 3 signaling pathway in colorectal cancer

作　　者：王慧慧[1] 赵婕[2] 李雪卿[2] Wang Huihui;Zhao Jie;Li Xueqing(Graduate School,Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学研究生学院,太原030001 [2]山西医科大学第二医院消化内科,太原030001

出　　处：《肿瘤研究与临床》2021年第11期877-880,共4页Cancer Research and Clinic

摘　　要：近年来,炎症与癌症的发生、发展受到人们的广泛关注,白细胞介素6(IL⁃6)作为一种促炎因子,在癌症进展中发挥一定的促进作用,是信号转导及转录激活因子3(STAT3)的重要活化因子。许多研究在结直肠癌中发现持续激活IL⁃6、STAT3信号通路可诱导与细胞增殖、凋亡和分化相关的癌基因的异常表达。现就IL⁃6、STAT3信号通路在结直肠癌发生、发展中的作用、预后及治疗中的临床价值等方面进行讨论,以期为结直肠癌患者病情监测、预后评估及治疗提供一定的理论依据。In recent years,the relationship between inflammation and the occurrence and development of cancer has attracted widespread attentions.As a pro⁃inflammatory factor,interleukin⁃6(IL⁃6)plays a certain role in promoting cancer progression,and it is an important activating factor of signal transducer and activator of transcription 3(STAT3).Many studies have shown that continuous activation of the IL⁃6 and STAT3 signaling pathway can induce the abnormal expression of oncogenes related to cell proliferation,apoptosis and differentiation in colorectal cancer.This article reviews the role of IL⁃6 and STAT3 signaling pathway in the occurrence and development of colorectal cancer,as well as the clinical value of this signaling pathway in the prognostic evaluation and treatment of colorectal cancer,in order to provide certain theoretical basis for the disease monitoring,prognostic evaluation and treatment of colorectal cancer.

关 键 词：结直肠肿瘤 白细胞介素6 信号转导及转录激活因子3 

分 类 号：R735.34[医药卫生—肿瘤]