外泌体非编码RNA在非小细胞肺癌获得性耐药中的研究进展  

Role of exosome-derived non-coding RNAs in drug resistance of non-small cell lung cancer cells

作　　者：赵林林[1] 王艳亭[2] 李小江[1] 李翀[1] 杨仕蕊[1] 顾丽丽[1] 王晓群[1] 陈鸿祥 贾英杰[1] Linlin Zhao;Yanting Wang;Xiaojiang Li;Chong Li;Shirui Yang;Lili Gu;Xiaoqun Wang;Hongxiang Chen;Yingjie Jia(Department of Oncology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Department of Medical Records,The Fourth People's Hospital of Jinan,Jinan 250031,China)

机构地区：[1]天津中医药大学第一附属医院肿瘤科,国家中医针灸临床医学研究中心,天津市300193 [2]济南市第四人民医院病案室

出　　处：《中国肿瘤临床》2022年第1期42-46,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然基金委员会面上项目(编号:81774054);天津市卫生健康委员会天津市中医药管理局中医中西医结合科研项目(编号:2019063)资助。

摘　　要：非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌中最常见的类型,对化疗及靶向药物的获得性耐药严重影响NSCLC患者的生存期,NSCLC获得性耐药机制复杂,确切机制仍不清楚。肿瘤来源或与肿瘤相关的外泌体是参与调控NSCLC获得性耐药的重要机制,可以通过传递核酸、蛋白质等赋予敏感细胞耐药性。本综述主要介绍近年来外泌体非编码RNA(noncoding RNA,ncRNA)在NSCLC获得性耐药中的研究进展。Non-small cell lung cancer(NSCLC)is the most common type of lung cancer.The acquisition of resistance to chemotherapy and targeted drugs seriously affects the survival of NSCLC patients.The exact mechanism whereby NSCLC patients acquire drug resistance is complex and remains unclear.Tumor-derived or tumor-related exosomes play an important role in the mechanism underlying,and regulation of,acquired drug resistance in NSCLC cells and endow sensitive cells with drug resistance via the transmission of nucleic acids and proteins.This review mainly introduces the progress of research regarding the roles of secreted non-coding RNAs(ncRNAs)in the acquired drug resistance of NSCLC cells in recent years.

关 键 词：非小细胞肺癌 外泌体 非编码RNA 获得性耐药 

分 类 号：R734.2[医药卫生—肿瘤]