铁死亡-多巴胺-神经黑色素调控轴在帕金森病中的作用  

Role of the ferroptosis-dopamine-neuromelanin regulatory net work in the pathogene⁃sis of Parkinson’s disease

作　　者：王梦笛 王洪财[1] WANG Meng-Di;WANG Hong-Cai(Department of Neurology,Binzhou Medical University Hospital,Binzhou,Shandong 256603,China)

机构地区：[1]滨州医学院附属医院神经内科,山东滨州256603

出　　处：《国际神经病学神经外科学杂志》2021年第6期564-566,共3页Journal of International Neurology and Neurosurgery

基　　金：国家自然科学青年基金(81601108);山东省自然科学青年基金(ZR2016HQ14)。

摘　　要：在帕金森病(PD)发病中氧化应激、线粒体功能障碍、α-突触核蛋白异常聚集等机制与铁死亡密切相关,铁死亡可能是各种机制的共同通路。铁死亡与多巴胺相互作用促进脂质氧化,减少神经黑色素合成,最终导致多巴胺神经元变性死亡,因此铁死亡-多巴胺-神经黑色素网络调控异常在PD发病中起着关键作用。本文就其在PD发病中作用的研究进展进行综述。Abnormal regulatory network of ferroptosis, dopamine and neuromelanin played an important role in the pathogenesis of Parkinson’s disease(PD), and the intrinsic mechanism remained to be elucidated. The effects of ferroptosis were correlated with oxidative stress, mitochondrial dysfunction and accumulation of α-synuclein, which might be the common pathways underlying PD pathogenesis. The interaction of ferroptosis and dopamine enhanced the production of lipid oxidation, decreased neuromelanin synthesis and lead to cell death. The research progress of the regulatory network of ferroptosis,dopamine and neuromelanin in PD was summarized.

关 键 词：帕金森病 铁死亡 多巴胺 神经黑色素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]