3-氰基吡啶的合成工艺优化  

Optimization of Synthetic Process of 3-Cyanopyridine

作　　者：李习红 刘皇见 吴李瑞 谷顺明 刘敏 LI Xi-hong;LIU Huang-jian;WU Li-rui;GU Shun-ming;LIU Min(Anhui Costar Biological Chemical Co.Ltd.,Anhui Heterocyclic Chemistry Provincial Laboratory,Maanshan 243100,China)

机构地区：[1]安徽国星生物化学有限公司,安徽杂环化学省级实验室,安徽马鞍山243100

出　　处：《安徽化工》2021年第6期107-109,共3页Anhui Chemical Industry

摘　　要：以Al;O;为载体,负载Cu、Na制备得到氨氧化催化剂,以固定床为反应器,将3-甲基吡啶和氨气、空气氧化,合成得到3-氰基吡啶。考查了Cu、Na含量,催化剂用量、原材料摩尔比、反应温度的影响。反应的最优条件为Cu含量2.5%,Na含量0.9%,反应温度340℃,催化剂用量6%,3-甲基吡啶/氨气(n/n)=1.05∶1,氨气/空气(n/n)=1∶9,此时3-甲基吡啶的收率高于92%。The ammonia oxidation catalyst was prepared with Al;O;as carrier,Cu supported and Na promoter.The 3-cyanopyridine was synthesized by oxidation of 3-methylpyridine with ammonia and air in a fixed bed reactor.The effects of Cu content,Na content,catalyst dosage,molar ratio of raw materials and reaction temperature were systematically investigated.The optimum reaction conditions are Cu content 2.5%,Na content 0.9%,reaction temperature 340℃,catalyst dosage 6%,3-methylpyridine/ammonia(n/n)=1.05∶1,ammonia/air(n/n)=1∶9.Under these conditions,the yield of 3-methylpyridine can reach above 92%.

关 键 词：氨氧化 3-甲基吡啶 3-氰基吡啶 固定床 氨气 

分 类 号：TQ921[轻工技术与工程—发酵工程]