信号转导和转录激活因子3及鳞状细胞癌抗原在喉癌中表达及其临床意义  

Expression of Signal Transducer and Activator of Transcription 3 and Squamous Cell Carcinoma Antigen in Laryngeal Carcinoma and Its Clinical Significance

作　　者：邵静[1] 魏鑫鑫[1] 范栩嫚 SHAO Jing;WEI Xinxin;FAN Xuman(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]南阳市中心医院,473000

出　　处：《实用癌症杂志》2022年第1期43-45,共3页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190046)。

摘　　要：目的探讨信号转导和转录激活因子3及鳞状细胞癌抗原在喉癌中表达及其临床意义。方法选取经活检或经手术治疗留取病理组织的患者68例。其中获取喉癌病理组织样本68例,癌旁组织25例。应用免疫组化法(SP)检测样品组织STAT3和SCC蛋白质表达水平。比较其阳性率,分析其与临床病理特征的关系。结果在喉癌组织中,STAT3和SCC阳性染色大部分出现于细胞质中,细胞核也见表达。喉癌病理组织中STAT3和SCC阳性率均明显高于癌旁组织(P<0.05)。临床分期Ⅰ+Ⅱ期、高分化、T1~T2浸润深度患者STAT3阳性率明显低于Ⅲ+Ⅳ期、中低分化、T3~T4浸润深度患者(P<0.05),临床分期Ⅰ+Ⅱ期、高分化、无淋巴结转移、T1~T2浸润深度患者SCC阳性率明显低于Ⅲ+Ⅳ期、中低分化、有淋巴结转移、T3~T4浸润深度患者(P<0.05)。结论喉癌组织中STAT3和SCC均呈过表达,STAT3和SCC均与喉癌临床病理特征相关。Objective To explore the expression of signal transducer and activator of transcription 3 and squamous cell carcinoma antigen in laryngeal carcinoma and its clinical significance.Methods 68 patients who received biopsy or surgical treatment of pathological tissues were selected.Among them,68 cases of pathological tissue samples of laryngeal cancer were obtained,and 25 cases of tissues adjacent to cancer were obtained.Use immunohistochemistry(SP)to detect the protein expression levels of STAT3 and SCC in sample tissues.Compare its positive rate and analyze its relationship with clinicopathological characteristics.Results In laryngeal cancer tissues,most of the positive staining of STAT3 and SCC appeared in the cytoplasm,and expression was also seen in the nucleus.The positive rates of STAT3 and SCC in the pathological tissues of laryngeal cancer were significantly higher than those of adjacent tissues(P<0.05).Clinical stageⅠ+Ⅱstage,well-differentiated,T1~T2 infiltration depth patients with STAT3 positive rate was significantly lower than that ofⅢ+Ⅳ,moderately poorly differentiated,T3~T4 infiltration depth patients(P<0.05),clinical stageⅠ+Stage II,well-differentiated,no lymph node metastasis,SCC positive rate in patients with T1 and T2 infiltration depth was significantly lower than that of stageⅢ+Ⅳ,moderately poorly differentiated,with lymph node metastasis,T3~T4 infiltration depth patients(P<0.05).Conclusion Both STAT3 and SCC are overexpressed.Both STAT3 and SCC are related to the clinicopathological characteristics of patients with laryngeal cancer.

关 键 词：信号转导和转录激活因子3 鳞状细胞癌抗原 喉癌 临床意义 

分 类 号：R739.65[医药卫生—肿瘤]