小切口甲状腺叶切除术对甲状腺肿瘤患者免疫功能及血清TG、钙水平的影响  

Effect of Small-incision Thyrolobectomy on Immune Function and Serum TG,Calcium Level in Thyroid Tumor Patients

作　　者：李明[1] 杨周[1] LI Ming;YANG Zhou(Jiamusi Central Hospital,Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2021年第36期56-60,共5页Medical Innovation of China

基　　金：黑龙江省卫生计生委科研项目(2013-155)。

摘　　要：目的:分析小切口甲状腺叶切除术对甲状腺肿瘤患者免疫功能及血清甲状腺球蛋白(TG)、钙水平的影响。方法:选取黑龙江省佳木斯市中心医院2017年3月-2018年10月收治的甲状腺肿瘤患者60例,根据随机数字表法分为对照组和观察组。对照组采用传统甲状腺瘤切除术,观察组采用小切口甲状腺叶切除术。比较两组术中出血量、切口长度、手术时间及住院时间,手术前后TG、钙、可溶性白细胞介素-2受体(sIL-2R)、白细胞分化抗原44变异型6(CD44V6)水平及T淋巴细胞亚群水平,并发症发生情况和复发情况。结果:观察组术中出血量少于对照组,切口长度、手术时间、住院时间均短于对照组(P<0.05)。术前,两组TG、钙、sIL-2R、CD44V6、T淋巴细胞水平比较,差异均无统计学意义(P>0.05);术后3 d,观察组钙水平高于对照组,TG、sIL-2R、CD44V6水平均低于对照组,免疫功能优于对照组(P<0.05)。观察组并发症发生率为10.00%,低于对照组的33.33%(P<0.05)。观察组复发率为3.33%,虽低于对照组的6.67%,但差异无统计学意义(P>0.05)。结论:小切口甲状腺叶切除术治疗甲状腺肿瘤术中出血量较少,可降低患者TG水平,改善免疫功能,安全性较高。Objective:To analyze the effect of small-incision thyrolobectomy on immune function and serum thyroglobulin(TG),calcium level in thyroid tumor patients.Method:A total of 60 patients with thyroid tumors treated in Jiamusi Central Hospital,Heilongjiang Province from March 2017 to October 2018 were divided into control group and observation group according to random number table method.The control group was treated with traditional thyroidectomy,and the observation group was treated with small-incision thyroidectomy.The amount of intraoperative bleeding,incision length,operation time and hospital stay,the levels of TG,calcium,soluble interleukin-2 receptor(sIL-2R),leukocyte differentiation antigen 44 variant 6(CD44V6)and T lymphocyte subsets before and after operation,the incidence of complications and recurrence were compared between the two groups.Result:Intraoperative blood loss in the observation group was less than that in the control group,incision length,operation time and hospitalization time were shorter in the observation group than those in the control group(P<0.05).Before operation,there were no significant differences in the levels of TG,calcium,sIL-2R,CD44V6 and T lymphocytes between the two groups(P>0.05);3 d after operation,the level calcium of in the observation group was higher than that in the control group,the levels of TG,sIL-2R and CD44V6 in the observation group were lower than those in the control group,and the immune function was better than that in the control group(P<0.05).The incidence of complications in the observation group was 10.00%,lower than 33.33%in the control group(P<0.05).The recurrence rate in the observation group was 3.33%,which was lower than 6.67%in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Small-incision thyrolobectomy for the treatment of intraoperative blood loss of thyroid tumors is less,which can reduce the TG level of patients,improve the immune function,and have higher safety.

关 键 词：小切口甲状腺叶切除术 甲状腺肿瘤 免疫功能 安全性 

分 类 号：R736.1[医药卫生—肿瘤]