Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer  

作　　者：Wenxiao Jiang Guiqing Cai Peter Hu Yue Wang 

机构地区：[1]Otogenetics Corp.,Atlanta,GA 30360,USA [2]Quest Diagnostics,San Juan Capistrano,CA 92675,USA [3]The University of Texas MD Anderson Cancer Center,Houston,TX 77030,USA [4]Department of Molecular and Human Genetics,Baylor College of Medicine,Houston,TX 77030,USA

出　　处：《Acta Pharmaceutica Sinica B》2021年第11期3406-3416,共11页药学学报（英文版）

摘　　要：Non-small cell lung cancer is recognized as the deadliest cancer across the globe.In some areas,it is more common in women than even breast and cervical cancer.Its rise,vaulted by smoking habits and increasing air pollution,has garnered much attention and resource in the medical field.The first lung cancer treatments were developed more than half a century ago.Unfortunately,many of the earlier chemotherapies often did more harm than good,especially when they were used to treat genetically unsuitable patients.With the introduction of personalized medicine,physicians are increasingly aware of when,how,and in whom,to use certain anti-cancer agents.Drugs such as tyrosine kinase inhibitors,anaplastic lymphoma kinase inhibitors,and monoclonal antibodies possess limited utility because they target specific oncogenic mutations,but other drugs that target mechanisms universal to all cancers do not.In this review,we discuss many of these non-oncogene-targeting anti-cancer agents including DNA replication inhibitors(i.e.,alkylating agents and topoisomerase inhibitors)and cytoskeletal function inhibitors to highlight their application in the setting of personalized medicine as well as their limitations and resistance factors.

关 键 词：Non-small cell lung cancer Personalized medicine PHARMACOGENOMICS PHARMACOGENETICS Drug resistance Vinca alkaloids Toxoids DNA replication inhibitors 

分 类 号：R734.2[医药卫生—肿瘤]