原发性椎管内硬膜外淋巴瘤49例病理类型构成分析  

Primary spinal epidural lymphoma: pathological typing of 49 cases

作　　者：岳冰[1] 张燕林[1] 郑媛媛[1] 王琳[1] 谢建兰[1] 周小鸽[1] YUE Bing;ZHANG Yan-lin;ZHENG Yuan-yuan;WANG Lin;XIE Jian-lan;ZHOU Xiao-ge(Department of Pathology,Beijing Friendship Hospital,Capital Medical University,Beijing100050,China)

机构地区：[1]首都医科大学附属北京友谊医院病理科,北京100050

出　　处：《诊断病理学杂志》2021年第12期1008-1011,1015,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨原发性椎管内硬膜外淋巴瘤(PSEL)患者的性别、年龄及病理类型构成特点。方法回顾性分析2008-01—2019-12首都医科大学附属北京友谊医院病理科本院外检及会诊病例中诊断为PSEL的病例共49例,分析患者的性别、发病年龄等临床资料及病理类型。结果 49例PSEL病例中,男性30例,女性19例,男女比为1.58∶1;年龄范围1~76岁,平均年龄40岁,中位年龄40岁,发病年龄与组织学类型有很大的关联,弥漫性大B细胞淋巴瘤(DLBCL)、黏膜相关淋巴组织(MALT)边缘区B细胞淋巴瘤(MALT淋巴瘤)、浆细胞瘤、滤泡性淋巴瘤(FL)更多见于中老年人,而B淋巴母细胞性淋巴瘤、Burkitt淋巴瘤(BL)更多见于儿童及青少年。病理类型上,霍奇金淋巴瘤(HL)3例(6.1%),非霍奇金淋巴瘤(NHL)46例(93.9%)。3例HL均为经典型霍奇金淋巴瘤(CHL),2例为结节硬化型,1例难以分出具体类型。46例NHL中,B细胞淋巴瘤占97.8%(45例),T/NK细胞淋巴瘤占2.2%(1例)。B细胞淋巴瘤中前五位为:DLBCL 35.6%(16例),B淋巴母细胞性淋巴瘤22.2%(10例),MALT淋巴瘤11.1%(5例),浆细胞瘤8.9%(4例),BL 6.7%(3例),FL 6.7%(3例)。1例T/NK细胞淋巴瘤为细胞毒性外周T细胞淋巴瘤。结论 PSEL中NHL最为多见,HL较少见。NHL中以B细胞淋巴瘤为主,T/NK细胞淋巴瘤较少见。各个类型淋巴瘤的性别及发病年龄也各有特点。Objective To investigate the characteristics of gender, age and pathological types of primary spinal epidural lymphoma(PSEL). Methods Forty-nine cases of PSEL were retrospectively analyzed from the Department of Pathology, Beijing Friendship Hospital, Capital Medical University during January 2008 to December 2019. The clinical data such as gender, age together with pathological types were reviewed. Results The 49 cases of PSEL included 30 males and 19 females. The male-to-female ratio was 1.58∶1. The age range was 1-76 years, with average and median age of 40 years. The age was strongly related to histological type. Diffuse large B-cell lymphoma(DLBCL), mucosa-associated lymphoid tissue(MALT) marginal zone B-cell lymphoma(MALT lymphoma), plasmacytoma, follicular lymphoma(FL) more commonly occured in middle-aged and elderly people, while B lymphoblastic lymphoma and Burkitt lymphoma(BL) were more frequently found in children and adolescents. In terms of pathological types, there were 3 cases(6.1%) of Hodgkin’s lymphoma(HL) and 46 cases(93.9%) of non-Hodgkin’s lymphoma(NHL). 3 cases of HL were all classical Hodgkin’s lymphoma(CHL), 2 cases were nodular sclerosis classical Hodgkin’s lymphoma, and 1 case was difficult to be classified as specific subtypes. Among 46 cases of NHL, B-cell lymphoma accounted for 97.8%(45 cases), and T/NK cell lymphoma accounted for 2.2%(1 cases). The top five B-cell lymphomas were: 35.6% of DLBCL(16 cases), 22.2% of B lymphoblastic lymphoma(10 cases), 11.1% of MALT lymphoma(5 cases), 8.9% of plasma cell tumor(4 cases), 6.7% of BL(3 cases), and 6.7% of( FL3 cases). T/NK cell lymphoma was cytotoxic peripheral T cell lymphoma. Conclusion In PSEL, NHL is more common, while HL is rare. B-cell lymphoma is predominant in NHL, while T/NK-cell lymphoma is rare. The gender and age of each type of lymphoma also have their own characteristics.

关 键 词：椎管内硬膜外 淋巴瘤 病理类型构成 

分 类 号：R733.41[医药卫生—肿瘤]