雄激素参与男性免疫炎性反应的研究进展  

Research progress of androgens involved in the male immune-inflammatory response

作　　者：蔡美丽 张曼娜[1,2] Cai Meili;Zhang Manna(Department of Endocrinology and Metabolism,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;National Metabolic Management Center,Shanghai 200072,China)

机构地区：[1]同济大学附属第十人民医院内分泌代谢科,上海200072 [2]国家标准化代谢病管理中心,上海200072

出　　处：《国际内分泌代谢杂志》2021年第6期653-656,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81601269)。

摘　　要：雄激素作为男性主要的性激素,除了在促进和维持男性第二性征发育方面有关键作用外,其在调节免疫炎性反应和免疫炎性相关性疾病方面亦发挥重要作用。越来越多的研究发现,雄激素与炎性相关标志物、免疫炎性反应相关基因、免疫炎性细胞及肠道菌群之间有着密切联系。因此,本综述拟围绕男性体内雄激素参与免疫炎性反应的最新进展展开,以全面认识雄激素在免疫炎性反应中的作用,旨在为临床上睾酮激素替代疗法改善男性患者全身慢性炎性反应状态及免疫炎性相关性疾病提供重要的指导依据。As the main sex hormones of men,androgens play an important role in promoting and maintaining the development of male secondary sexual characteristics.Besides,they also play an important role in regulating immune inflammation response and immune inflammation-related diseases.Multiple studies have found that androgens are closely related to inflammation-related markers,immune-inflammatory response-related genes,immune-inflammatory cells,and intestinal flora.Therefore,this review intends to focus on the latest progress of androgens in the immune-inflammatory response in men,to comprehensively understand the importance of androgens in the immune-inflammatory response,and aim to provide vital guidance for clinical testosterone replacement therapy to improve the systemic chronic inflammatory state and immune inflammation-related diseases in male patients.

关 键 词：雄激素 炎性反应 炎性细胞因子 炎性标志物 

分 类 号：R364.5[医药卫生—病理学]