术后使用酮咯酸氨丁三醇与布托啡诺对肿瘤患者镇痛及炎症因子的影响  

Effects of Ketorolac Tromethamine Combined with Butorphanol on Analgesia and Inflammatory Factors in Postoperative Tumor Patients

作　　者：胡志强[1] 顾贤成[1] 周炎[1] 吴泊[1] HU Zhiqiang;GU Xiancheng;ZHOU Yan;WU Bo(Yixing Hospital Affiliated to Jiangsu University,Yixing 214200,China)

机构地区：[1]江苏大学附属宜兴医院,江苏宜兴214200

出　　处：《中外医学研究》2022年第2期29-32,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：无锡市卫生健康委科研项目(Z201907)。

摘　　要：目的:探讨术后采用酮咯酸氨丁三醇与布托啡诺联用对肿瘤患者镇痛及炎症因子的影响。方法:选取2018年3月-2020年9月就诊于江苏大学附属宜兴医院肿瘤科的术后肿瘤患者80例,采用抽签法随机分为两组,各40例。两组术后均连接自控静脉镇痛泵,对照组给予布托啡诺,研究组给予布托啡诺联合酮咯酸氨丁三醇。比较两组术后2、12、24、48 h的疼痛视觉模拟(VAS)评分、Ramsay镇静评分、镇痛泵按压次数,术后2、48 h两组炎症因子(IL-1β、IL-6、IL-10)水平及不良反应发生率。结果:相比于对照组,研究组术后12、24、48 h的VAS评分较低,术后48 h镇痛泵总按压次数较少(P<0.05);两组Ramsay镇静评分与不良反应发生率比较,差异无统计学意义(P>0.05);术后2、48 h,研究组的IL-1β与IL-6水平低于对照组,IL-10水平高于对照组(P<0.05)。结论:布托啡诺联合酮咯酸氨丁三醇用于肿瘤患者术后静脉自控镇痛治疗,镇痛效果较好,疗效确切,不良反应发生率低,且可有效降低炎症因子,安全性较高,临床可广泛推进。Objective:To investigate the effects of Ketorolac Tromethamine combined with Butorfenol on analgesia and inflammatory factors in postoperative tumor patients.Method:A total of 80 perioperative cancer patients admitted to the oncology department of Yixing Hospital Affiliated to Jiangsu University from March 2018 to September 2020 were randomly divided into two groups with 40 cases in each group by drawing lots.After operation,both groups were connected with self-controlled intravenous analgesia pump,the control group was treated with Butorphanol,while the study group was treated with Butorphanol combined with Ketorolac Tromethamine.The visual analogue of pain(VAS)score,Ramsay sedation score for sedation,and the number of analgesic pump compressions were compared between the two groups of patients at 2,12,24,48 hours after surgery.The inflammatory factors(IL-1β,IL-6,IL-10)levels at 2 and 48 h after surgery and the incidence of adverse reactions in the two groups were compared.Result:Compared with the control group,the VAS score of the study group at 12,24 and 48 hours after surgery were lower,and the total number of analgesic pump compressions 48 h after surgery was less(P<0.05).There were no significant differences in the Ramsay sedation score and the incidence of adverse reactions between the two groups(P>0.05);at 2 and 48 hours after surgery,the levels of IL-1βand IL-6 were lower than those of the control group,while the level of IL-10 was higher than that in the control group(P<0.05).Conclusion:Butorphanol combined with Ketorolac Tromethamine is used for patient-controlled intravenous analgesia in patients with tumor after surgery,which has good analgesic effect,definite curative effect and low incidence of adverse reactions,and can effectively reduce inflammatory factors,with high safety and can be widely promoted clinically.

关 键 词：镇痛 酮咯酸氨丁三醇 布托啡诺 炎症因子 

分 类 号：R730.5[医药卫生—肿瘤]