血清载脂蛋白A-Ⅰ水平在远端胃癌D2根治术预后中的意义分析  

Significance of serum apolipoprotein A-Ⅰin prognosis of distal gastric cancer after D2 radical gastrectomy

作　　者：夏云展[1] 李琼[2] 李荣振[1] 朱少功[1] 李晓彦[1] XIA Yunzhan;LI Qiong;LI Rongzhen;ZHU Shaogong;LI Xiaoyan(General Surgery Department,People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China;Department of Neurology,People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州人民医院普通外科,河南郑州450000 [2]郑州人民医院神经内科,河南郑州450000

出　　处：《中国医学工程》2022年第1期25-28,共4页China Medical Engineering

摘　　要：目的探讨术前血清载脂蛋白A-Ⅰ(ApoA-Ⅰ)在远端胃癌D2根治术预后评估中的价值。方法检测行远端胃癌D2根治术的87例胃癌患者的血清ApoA-Ⅰ水平,根据中位值(1.14 g/L)将患者分为低ApoA-Ⅰ组(n=44)和高ApoA-Ⅰ组(n=43),分析比较两组患者病理特征及术后恢复情况的差异,分别采用Kaplan-Meier法、单因素及多因素Cox回归分析ApoA-Ⅰ水平与远端胃癌D2根治术患者术后生存期的关系。结果高ApoA-Ⅰ组和低ApoA-Ⅰ组在TNM分期上差异有统计学意义(P<0.05);高ApoA-Ⅰ组术后并发症发生率低于低ApoA-Ⅰ组(P<0.05),术后总生存期高于低ApoA-Ⅰ组(P<0.05);ApoA-Ⅰ是患者术后总生存期的独立保护因素(P<0.05)。结论血清ApoA-Ⅰ水平可能是远端胃癌D2根治术患者预后的保护因素之一。【Objective】To study the significance of preoperative serum apolipoprotein A-Ⅰ(ApoA-Ⅰ)on prognosis assessment of distal gastric cancer after D2 radical value.【Methods】The serum ApoA-Ⅰlevels of 87 distal gastric cancer patients who underwent D2 radical operation were detected,and the patients were divided into the low ApoA-Ⅰgroups(n=44)and high ApoA-Ⅰgroup(n=43)according to the median(1.14 g/L),the pathological characteristics and postoperative recovery were compared between the two groups,Kaplan-Meier method,single factor and multiple factors COX regression were used to analyze the correlation of ApoA-Ⅰand postoperative survival in patients with distal gastric cancer after D2 radical operation.【Results】High ApoA-Ⅰgroup and low ApoA-Ⅰgroup had statistically differences in TNM stage(P<0.05).The incidence of postoperative complications in high ApoA-Ⅰgroup was lower than that in low ApoA-Ⅰgroup(P<0.05),the overall survival after surgery in high ApoA-Ⅰgroup was higher than that in ApoA-Ⅰgroup(P<0.05).ApoA-Ⅰwas an independent protective factors of overall survival of distal gastric cancer patients after D2 radical operation(P<0.05).【Conclusion】The level of serum ApoA-Ⅰmay be one of the the protective factors for the prognosis of distal gastric cancer patients after D2 radical operation.

关 键 词：D2根治术 远端胃癌 载脂蛋白A-Ⅰ 预后 生存期 

分 类 号：R735.2[医药卫生—肿瘤]