病证结合模式下肺癌实验动物模型的研究进展  

Progress in experimental lung cancer animal model under the combination of disease and syndrome

作　　者：谭骏岚 易健 王飞英[1] 万佳婧 覃丽 戴爱国 TAN Junlan;YI Jian;WANG Feiying;WAN Jiajing;QIN Li;DAI Aiguo(Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine,Medical School,Hunan University of Chinese Medicine,Changsha 410208,China;Division of Stem Cell Regulation and Application,Hunan University of Chinese Medicine,Changsha 410208;Department of Respiratoiy Medicine,the First Affiliated Hospital,Hunan University of Chinese Medicine,Changsha 410021)

机构地区：[1]湖南中医药大学医学院-血管生物学与转化医学湖南省高校重点实验室,长沙410208 [2]湖南中医药大学干细胞中药调控与应用实验室,长沙410208 [3]湖南中医药大学第一附属医院呼吸科,长沙410021

出　　处：《中国比较医学杂志》2022年第1期111-119,共9页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81973668);血管生物学与转化医学湖南省普通高等学校重点实验室(湘教通[2021]241号)。

摘　　要：肺癌(lung cancer)的高发病率与高死亡率对人民健康造成了极大的危害。中医药在恶性肿瘤的防治方面具有广泛的临床经验,在治疗肺癌方面也显示出明显的优势。实验动物模型是肺癌研究领域中必不可少的一部分。构建中医特色的病证结合动物模型是以中医辨证论治理论为基础,将中医证候纳入了评价标准,使动物模型既符合西医疾病特征又具备中医证候的特点。本文总结了当前常用的肺癌动物模型和病证结合动物模型的构建方法与特点,以期为从事肺癌科学研究的中西医科研工作者提供参考。Lung cancer is a malignant tumor with high mortality and morbidity and causes great harm to human health.Traditional Chinese medicine(TCM)has extensive clinical experience in the prevention and treatment of malignant tumor,and it also shows clear advantages in the treatment of lung cancer.Experimental animal models are an essential part of the lung cancer research field.The construction of the animal model of disease and syndrome combination with TCM characteristics is based on the the theory of syndrome differentiation and treatment in TCM,and the TCM symptoms are included in the evaluation criteria,so that the animal model conforms to the characteristics of western medicine disease and has the characteristics of TCM symptoms.This review summarizes the method and characteristics of commonly used lung cancer animal models and disease syndrome combination models to provide a reference for researchers engaged in lung cancer experimental research.

关 键 词：肺癌 病证结合 实验动物模型 造模方法 

分 类 号：R-33[医药卫生]