丁苯酞治疗脑出血合并肺部感染的疗效及其对CGRP、BDNF影响  

Efficacy of butylphthalide in the treatment of cerebral hemorrhage complicated with pulmonary infection and its effect on CGRP and BDNF

作　　者：黄贞仪 郭林[1] 罗珠河 HUANG Zhenyi;GUO Lin;LUO Zhuhe(Department of Pharmacy,Huizhou First People's Hospital,Huizhou,Guangdong,China,516001;Department of Pharmacy,Huizhou Central People's Hospital,Huizhou,Guangdong,China,516001)

机构地区：[1]惠州市第一人民医院药学部,广东惠州516001 [2]惠州中心人民医院药学部,广东惠州516001

出　　处：《分子诊断与治疗杂志》2022年第1期63-66,72,共5页Journal of Molecular Diagnostics and Therapy

基　　金：惠州市科技计划项目(2017Y045)。

摘　　要：目的探讨丁苯酞治疗合并脑出血合并肺部感染的疗效及其对降钙素基因相关肽(CGRP)、脑源性神经营养因子(BDNF)影响。方法选择2018年1月至2020年6月惠州市第一人民医院收治的124例脑出血合并肺部感染患者,按照随机数字表法分为对照组和观察组,每组各62例。对照组采用常规治疗,观察组在对照组的基础上采用丁苯酞氯化钠注射液治疗,两组均治疗14 d。观察两组治疗前后国立卫生研究院卒中量表(NIHSS)评分、血清CGRP、BDNF水平,比较两组临床疗效,观察两组治疗期间不良反应发生情况。结果治疗后两组NIHSS评分均降低,且观察组更低,差异有统计学意义(P<0.05);治疗后两组血清CGRP水平均下降,且观察组更低,差异均有统计学意义(P<0.05);治疗后两组血清BDNF水平均升高,且观察组更高,差异均有统计学意义(P<0.05);观察组总有效率比对照组高差异有统计学意义(64.52%vs.46.77%,P<0.05);两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用丁苯酞治疗脑出血合并肺部感染患者,疗效显著,可调节患者血清CGRP、BDNF水平,改善患者的神经功能,且安全可靠。Objective To investigate the efficacy of butylphthalide in the treatment of cerebral hemorrhage complicated with pulmonary infection and its effect on calcitonin gene-related peptide(CGRP)and brain-derived neurotrophic factor(BDNF).Methods A total of 124 patients with cerebral hemorrhage and pulmonary infection admitted to Huizhou First People’s Hospital from January 2018 to June 2020 were selected and divided into control group and observation group according to the random number table method,with 62 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with butylphthalide sodium chloride injection on the basis of the control group.Both groups were treated for 14 days.The National Institutes of Health Stroke Scale(NIHSS)scores,serum CGRP and BDNF levels were observed before and after treatment in the two groups.The clinical efficacy of the two groups were compared.The occurrence of adverse reactions during the treatment period of the two groups were observed.Results After treatment,the NIHSS scores of the two groups were decreased(P<0.05),and the observation group was even lower,and the difference was statistically significant(P<0.05).After treatment,the serum CGRP levels in the two groups were decreased,and the observation group was lower,and the differences were statistically significant(P<0.05).After treatment,the levels of serum BDNF in the two groups were increased,and the observation group was higher,and the differences were statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group(64.52%vs.46.77%,P<0.05).There were no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion The use of butylphthalide in the treatment of patients with cerebral hemorrhage complicated by pulmonary infection has a significant effect,can regulate the serum CGRP and BDNF levels of patients,and improve the neurological function of patient

关 键 词：丁苯酞 肺部感染 脑出血 降钙素基因相关肽 脑源性神经营养因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R563.1[医药卫生—临床医学]