血清CEACAM-1、CA199、MIC-1联合检测在胰腺癌诊断中的临床价值  

Clinical value of combined detection of serum CEACAM-1,CA199 and MIC-1 in the diagnosis of pancreatic cancer

作　　者：张金令 王青青 魏艳蕾 陈秀霞 ZHANG Jinling;WANG Qingqing;WEI Yanlei;CHEN Xiuxia(Department of Internal Medicine,Dongying District People's Hospital,Dongying,Shandong,China,257000;Department of Laboratory Medicine,Dongying District People's Hospital,Dongying,Shandong,China,257000;Department of Laboratory Medicine,Dongying People's Hospital,Dongying,Shandong,China,257091)

机构地区：[1]东营市东营区人民医院内科,山东东营257000 [2]东营市东营区人民医院检验科,山东东营257000 [3]东营市人民医院检验科,山东东营257091

出　　处：《分子诊断与治疗杂志》2022年第1期108-111,共4页Journal of Molecular Diagnostics and Therapy

基　　金：山东省科技发展计划项目(2018-1023)。

摘　　要：目的分析血清癌胚抗原相关细胞黏附分子1(CEACAM-1)、糖蛋白抗原199(CA199)、巨噬细胞抑制因子-1(MIC-1)联合检测在胰腺癌诊断中的临床价值。方法选取东营市东营区人民医院2018年5月至2021年5月收治的58例胰腺癌患者(胰腺癌组)和61例良性胰腺疾病患者(良性胰腺疾病组)的临床资料,另选取同期60例健康体检者(对照组),比较三组血清CEACAM-1、CA199、MIC-1水平变化,绘制受试者工作特征曲线(ROC),分析血清CEACAM-1、CA199、MIC-1联合检测在胰腺癌诊断中的应用价值。结果三组心率差异无统计学意义(P>0.05)。收缩压、舒张压、白细胞计数与血清CRP、CEACAM-1、CA199、MIC-1水平:胰腺癌组>良性胰腺疾病组>对照组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,CEACAM-1、CA199、MIC-1与胰腺癌高度相关(P<0.05)。ROC曲线分析显示,CEACAM-1、CA199、MIC-1三者联合检测的AUC为0.971,明显高于CA199(Z=2.577,P=0.010),但与其他血清指标检测结果差异无统计学意义(P>0.05),以0.315为临界值时,其敏感性、特异性分别为94.83%、93.44%。结论血清CEACAM-1、CA199、MIC-1均可作为诊断胰腺癌的可靠肿瘤标志物,联合检测可显著提高诊断效能。Objective To analyze the clinical value of combined detection of serum carcinoembryonic antigen-related cellular adhesion molecule 1(CEACAM-1),carbohydrate antigen-199(CA199)and macrophage inhibitory cytokine 1(MIC-1)in the diagnosis of pancreatic cancer.Methods The clinical data of58 patients with pancreatic cancer(pancreatic cancer group)and 61 patients with benign pancreatic disease(benign pancreatic disease group)admitted from May 2018 to May 2021 in Dongying District People’s Hospital of Dongying City were selected.In addition,60 cases of healthy physical examination during the same period were selected as the control group.The changes in serum CEACAM-1,CA199 and MIC-1 levels were compared among the three groups.The receiver operating characteristic(ROC)curve was plotted to analyze the application value of combined detection of serum CEACAM-1,CA199 and MIC-1 in the diagnosis of pancreatic cancer.Results There was no significant difference in heart rate among the three groups(P>0.05).The results of systolic blood pressure,diastolic blood pressure,white blood cell count and the levels of serum CRP,CEACAM-1,CA199,MIC-1 decreased in order from the pancreatic cancer group,the benign pancreatic disease group to the control group(P<0.05).Logistic regression analysis showed that CEACAM-1,CA199,MIC-1 were highly correlated with pancreatic cancer(P<0.05).The ROC curve analysis showed that the AUCof the combined detection of CEACAM-1,CA199,and MIC-1 was 0.971,which was significantly higher than that of CA199(Z=2.577,P=0.010),but there was no statistically significant difference between the detection results of other serum indicators(P>0.05),with 0.315 as the critical value,the sensitivity and specificity were94.83%and 93.44%,respectively.Conclusion Serum CEACAM-1,CA199,and MIC-1 can be used as reliable tumor markers for the diagnosis of pancreatic cancer,and the combined detection can significantly improve the diagnostic efficiency.

关 键 词：胰腺癌 血清癌胚抗原相关细胞黏附分子1 糖蛋白抗原199 巨噬细胞抑制因子-1 

分 类 号：R735.9[医药卫生—肿瘤]