经动脉灌注化疗辅助静脉化疗对无法手术晚期胃癌患者的治疗效果  

The effect of arterial infusion chemotherapy and intravenous chemotherapy on patients with inoperable advanced gastric cancer

作　　者：王鹤鸣[1] 付来琳 张鸣鸣[1] WANG Heming;FU Lailin;ZHANG Mingming(Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]青岛市市立医院消化内科,山东青岛266000

出　　处：《中国肿瘤外科杂志》2021年第6期601-605,共5页Chinese Journal of Surgical Oncology

摘　　要：目的研究经动脉灌注化疗辅助静脉化疗对无法手术的晚期胃癌患者的治疗效果。方法选取青岛市市立医院消化内科2014年6月—2017年7月收治的晚期胃癌患者104例,其中60例采用全身静脉化疗(静脉组),44例采用经动脉灌注化疗联合全身静脉化疗(联合组);比较两组化疗后的效果、化疗期间的不良反应及化疗前后患者血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、组织多肽特异性抗原(TPS)水平,比较两组的2年生存率及总生存时间。结果联合组患者的总有效率(75.00%)高于静脉组(53.33%),差异有统计学意义(P<0.05);化疗前,联合组与静脉组的血清CEA、CA125、CA19-9、TPS水平差异无统计学意义(P>0.05);化疗后,两组患者的血清CEA、CA125、CA19-9、TPS水平均较本组化疗前降低,且联合组低于静脉组,差异有统计学意义(P<0.05);两组患者的骨髓抑制、血红蛋白降低、血小板减少、恶心呕吐、腹泻、口腔黏膜炎、肝肾损伤的发生程度差异无统计学意义(P>0.05);两组2年随访失访率、2年生存率差异无统计学意义(P>0.05);联合组的总生存时间(19个月)长于对照组(12个月),差异有统计学意义(P<0.05)。结论经动脉灌注化疗辅助静脉化疗对延长无法手术晚期胃癌患者的生存期有一定益处。Objective To explore the therapeutic effect of intra-arterial infusion chemotherapy and intravenous chemotherapy for patients with inoperable advanced gastric cancer.Methods A total of 104 patients with advanced gastric cancer admitted to the Department of Gastroenterology,Qingdao Municipal Hospital from June 2014 to July 2017 were selected.Among them,60 received systemic intravenous chemotherapy(intravenous group)and 44 received transarterial infusion chemotherapy combined with systemic intravenous chemotherapy(combined group).Compare the effects of chemotherapy,adverse reactions during chemotherapy,and serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA19-9),and tissue polypeptide specific antigen(TPS)levels in patients before and after chemotherapy.Compare the 2-year survival rate and overall survival time.Results The total effective rate(75.00%)of the combined group was higher than that of the intravenous group(53.33%),and the difference was statistically significant(P<0.05);Before chemotherapy,there was no significant difference in serum CEA,CA125,CA19-9 and TPS levels between the combined group and the intravenous group(P>0.05);After chemotherapy,the serum levels of CEA,CA125,CA19-9 and TPS of the two groups of patients were lower than those of this group before chemotherapy,and the combined group was lower than that of the intravenous group,the difference was statistically significant(P<0.05);There was no significant difference in the incidence of bone marrow suppression,hemoglobin reduction,thrombocytopenia,nausea and vomiting,diarrhea,oral mucositis,liver and kidney damage between the two groups of patients(P>0.05);The two-year follow-up loss rate and 2-year survival rate were not statistically different between the two groups(P>0.05);the overall survival time of the combination group(19 months)was longer than that of the control group(12 months),and the difference was statistically significant(P<0.05).Conclusions Intra-arterial infusion chemotherapy and intrav

关 键 词：经动脉灌注化疗 静脉化疗 晚期胃癌 生存率 

分 类 号：R735.2[医药卫生—肿瘤]