吲哚布芬联合氯吡格雷治疗进展性缺血性脑卒中的效果分析  

Analysis of the Effect of Indobufen Combined with Clopidogrel in the Treatment of Progressive Ischemic Stroke

作　　者：单树崇 于春雨[1] SHAN Shuchong;YU Chunyu(Xuzhou First People’s Hospital,Jiangsu Province,Xuzhou 221000,China;不详)

机构地区：[1]江苏省徐州市第一人民医院,江苏徐州221000

出　　处：《中国医学创新》2022年第1期141-144,共4页Medical Innovation of China

摘　　要：目的:探讨吲哚布芬联合氯吡格雷治疗进展性缺血性脑卒中的效果。方法:选择徐州市第一人民医院的进展性缺血性脑卒中患者90例作为研究对象,收集时间为2019年1月-2021年1月,均入院确诊,采用随机数字表法分为对照组与观察组,各45例,对照组采取常规基础治疗及氯吡格雷治疗,观察组在此基础上联合吲哚布芬治疗。评价两组治疗效果,测评两组神经功能缺损程度,观察用药不良反应发生情况,测定血液指标变化。结果:治疗7、14 d后,与对照组比较,观察组美国国立卫生研究院脑卒中量表(NIHSS)评分及CRP水平均显著更低(P<0.05)。观察组治疗有效率为95.56%,与对照组77.78%比较显著更高(P<0.05)。观察组不良反应发生率为8.89%,与对照组6.67%比较,差异无统计学意义(P>0.05)。治疗后,观察组全血低切及高切黏度、血小板聚集率、纤维蛋白原均显著低于对照组(P<0.05)。结论:进展性缺血性脑卒中患者在常规治疗基础上实施吲哚布芬联合氯吡格雷用药方案可取得良好的疗效,有效减轻神经功能缺损症状,改善神经功能、血液流变学指标及凝血指标,而且联合用药无严重不良反应,安全性较高,值得推广应用。Objective:To investigate the effect of Indobufen combined with Clopidogrel in the treatment of progressive ischemic stroke.Method:A total of ninety patients with progressive ischemic stroke from Xuzhou First People’s Hospital were selected as the research objects.The collection time was from January 2019 to January 2021.All were admitted to the hospital for diagnosis.They were randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with conventional basic treatment and Clopidogrel,and the observation group was treated with Indobufen on this basis.The treatment effects and the degree of neurological deficits in the two groups were evaluated,the occurrence of adverse drug reactions was observed,and changes in blood indicators were measured.Result:After 7 and 14 d of treatment,compared with the control group,the national institutes of health stroke scale(NIHSS)scores and CRP levels of the observation group were significantly lower(P<0.05).The total effective rate of the observation group was 95.56%,which was significantly higher than 77.78%of the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.89%,which was not statistically significant compared with 6.67%in the control group(P>0.05).After treatment,the low-cut and high-cut whole blood viscosity,platelet aggregation rate and fibrinogen of the observation group were significantly lower than those of the control group(P<0.05).Conclusion:Indobufen combined with Clopidogrel on the basis of conventional treatment for patients with progressive ischemic stroke can achieve good curative effect,effectively alleviate the symptoms of neurological deficit,improve neurological function,restore basic ability of daily living,and improve Hemorheology indicators and coagulation indicators,and the combination has no serious adverse reactions,high safety,and it is worthy of popularization and application.

关 键 词：吲哚布芬 氯吡格雷 缺血性脑卒中 神经功能 不良反应 炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]