β-胡萝卜素的体内代谢及与维生素A的生物转化  

Metabolism and Biotransformation ofβ-Carotenoids

作　　者：李若茗 董慧[3] 陈哲晖 魏然 陈超阳[1,2] 周颖 杨艳玲[3] 崔一民[1,2,4] LI Ruo-ming;DONG Hui;CHEN Zhe-hui;WEI Ran;CHEN Chao-yang;ZHOU Ying;YANG Yan-ling;CUI Yi-min(Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;Department of Pharmacy Administration and Clinical Pharmacy,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China;Department of Pediatrics,Peking University First Hospital,Beijing 100034,China;Institute of Clinical Pharmacology,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第一医院药学部,北京100034 [2]北京大学药学院药事管理与临床药学系,北京100191 [3]北京大学第一医院儿科,北京100034 [4]北京大学临床药理研究所,北京100191

出　　处：《罕少疾病杂志》2022年第3期1-4,18,共5页Journal of Rare and Uncommon Diseases

基　　金：国家科技重大专项项目(2018ZX09721003-008);国家科技重大专项项目(2017ZX09304029-006-001)。

摘　　要：类胡萝卜素是在大多数植物、藻类和光合细菌中存在的天然色素。β-胡萝卜素的体内代谢过程受多种因素的影响,动物模型研究证实参与β-胡萝卜素代谢的关键基因变异可诱发各种病理表现。本综述总结了β-胡萝卜素的吸收与代谢、生物转化及高胡萝卜素血症相关的研究结果,以期为β-胡萝卜素的摄入及高胡萝卜素血症诊疗提供参考。Carotenoids are natural pigments found in plants,algae and photosynthetic bacteria.The metabolic process ofβ-carotene in vivo is affected by many factors.Key gene variations involved inβ-carotene metabolism can induce various pathological manifestations in animal models.This review summarizes the studies of the absorption,metabolism and biotransformation ofβ-carotene,as well as studies of hypercarotenemia,in order to provide reference for intakingβ-carotene and the diagnosis and treatment of hypercarotenemia.

关 键 词：类胡萝卜素 Β-胡萝卜素 维生素A 高胡萝卜素血症 

分 类 号：R977.21[医药卫生—药品]