微创旋切术治疗乳腺良性肿瘤患者的效果及其对手术指标和免疫功能的影响  

Effect of Minimally Invasive Rotatory Resection in Patients with Benign Breast Tumors and Its Effect on Surgical Indexes and Immune Function

作　　者：陈雷 郭德阳 CHEN Lei;GUO Deyang(Chongqing Yubei District People’s Hospital,Chongqing 401120,China;不详)

机构地区：[1]重庆市渝北区人民医院,重庆401120 [2]重庆医科大学附属永川医院

出　　处：《中外医学研究》2022年第3期38-41,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨微创旋切术在乳腺良性肿瘤患者中的治疗效果及其对手术指标和免疫功能的影响。方法:将重庆医科大学附属永川医院2016年7月-2019年4月确诊并接受手术治疗的546例女性乳腺良性肿瘤患者作为研究对象,按照患者自愿原则,将患者分为对照组(273例)和观察组(273例)。对照组采用传统开放手术治疗,观察组采用微创旋切术治疗,对比两组临床疗效,手术指标(手术时间、术中出血量、切口长度、瘢痕长度、切口愈合时间)和术前、术后1个月的免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。结果:每6个月复查随访一次,随访2年后,观察组优良率为97.07%(265/273),高于对照组的76.92%(210/273),差异有统计学意义(P<0.05);观察组手术时间、切口长度、瘢痕长度、切口愈合时间均短于对照组,术中出血量少于对照组(P<0.05);术前两组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较差异均无统计学意义(P>0.05),术后1个月两组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平均得到有效改善,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组(P<0.05)。结论:微创旋切术用于乳腺良性肿瘤患者治疗中,临床效果更加确切,缩短了患者手术时间,减少了出血量,创伤性小,术后瘢痕小,还促进机体的免疫功能恢复,改善了免疫功能,是临床上值得应用的微创肿瘤切除方式。Objective:To investigate the therapeutic effect of minimally invasive rotatory resection in patients with benign breast tumor and its effect on surgical indexes and immune function.Method:A total of 546 female patients with benign breast tumor diagnosed and treated in Yongchuan Hospital Affiliated to Chongqing Medical University from July 2016 to April 2019 were selected as the research subjects,according to the patients’voluntary principle,the patients were divided into control group(273 cases)and observation group(273 cases).The control group was treated with the treatment of traditional open surgery,the observation group was treated with the treatment of minimally invasive rotatory resection.Clinical efficacy,surgical indexes(operative time,intraoperative blood loss,incision length,scar length,and incision healing time)and immune function indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))before and one month after surgery were compared between the two groups.Result:Follow-up was conducted every 6 months,and after 2 years of follow-up,the good rate of the observation group was 97.07%(265/273),which was higher than 76.92%(210/273)of the control group,the difference was statistically significant(P<0.05);the operative time,incision length,scar length and incision healing time of the observation group were shorter than those of the control group,and the intraoperative blood loss of the observation group was less than that of the control group(P<0.05);there were no significant differences in the levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the two groups before surgery(P>0.05),one month after surgery,the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)were effectively improved in the two groups,and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,while CD8^(+)was lower than that in the control group(P<0.05).Conclusion:Minimally invasive rotatory resection used in the treatment of patients with benign breast tumor has more precise clinical

关 键 词：乳腺良性肿瘤 微创旋切术 免疫功能指标 手术指标 切口长度 

分 类 号：R737.9[医药卫生—肿瘤]