CTA评估缺血性脑血管病患者颈动脉粥样硬化程度与Cys-C、Hcy指标相关性分析  

Correlation Between the Degree of Carotid Atherosclerosis and the Cys-C and Hcy Indexes Evaluated by CTA in Patients with Ischemic Cerebrovascular Disease

作　　者：贾建普[1] 张乐国[1] 王丽轩[1] 姬春雪[1] 夏瑞雪[1] 张俊玲[1] JIA Jian-pu;ZHANG Le-guo;WANG Li-xuan;JI Chun-xue;XIA Rui-xue;ZHANG Jun-ling(The Second Department of Neurology,Cangzhou Central Hospital,Cangzhou 061001,Hebei Province,China)

机构地区：[1]沧州市中心医院脑科医院神经内二科,河北沧州061001

出　　处：《中国CT和MRI杂志》2022年第3期11-13,共3页Chinese Journal of CT and MRI

基　　金：沧州市科技计划项目(131302052)。

摘　　要：目的分析CT血管成像(CTA)评估缺血性脑血管病患者颈动脉粥样硬化程度与血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)指标相关性。方法选取本院2018年4月至2019年6月收治的172例缺血性脑血管疾病患者作为研究对象,根据CTA检查评估颈动脉粥样硬化程度,利用CTA联合彩超对颈动脉斑块进行分级,分析动脉内-中膜不同厚度者的Cys-C、Hcy指标水平的差异。结果172例患者经CTA检查发现,动脉轻度、中度、重度狭窄分别为16例、39例、28例;动脉内-中膜厚度(IMT)正常者有52例,IMT增厚者31例,其余89例患者均有斑块形成,其中硬斑块22例,软斑块34例,混合斑块33例;IMT正常者的Cys-C、Hcy水平明显低于IMT增厚组者、斑块形成者,其中斑块形成组Cys-C、Hcy水平最高(P<0.05),Logistic回归分析结果显示,Cys-C、Hcy水平升高为动脉粥样硬化斑块形成的独立危险因素(P<0.05)。结论Cys-C和Hcy与颈动脉粥样硬化发生发展具有一定相关性,CTA可有效显示缺血性脑血管病患者颈动脉粥样硬化程度,对早期评估缺血性脑血管病作用重大。Objective To analyze the correlation between the degree of carotid atherosclerosis and the cystatin C(Cys-C)and homocysteine(Hcy)indexes evaluated by CT angiography(CTA)in patients with ischemic cerebrovascular disease.Methods 172 patients with ischemic cerebrovascular disease treated in our hospital from April 2018 to June 2019 were selected as the research objects.The degree of carotid atherosclerosis was evaluated by the CTA examination,and and the carotid plaque was graded by CTA combined with color ultrasound.The differences in Cys-C and Hcy levels in patients with different carotid intima-media thickness were analyzed.Results CTA examination of 172 patients showed that there were 16 cases with arterial mild stenoses,39 cases with moderate stenoses,and 28 cases with severe stenoses.There were 52 cases with normal intra-media thickness(IMT),31 cases with thickened IMT,and plaque formation was found in the remaining 89 patients,in which 22 cases had hard plaques,34 cases had soft plaques,and 33 cases had mixed plaques.The levels of Cys-C and Hcy in patients with normal IMT were significantly lower than those in patients with thickened IMT and plaque formation.Among them,the levels of Cys-C and Hcy in the plaque formation group were the highest(P<0.05).Logistic regression analysis showed that elevated Cys-C and Hcy levels were independent risk factors for atherosclerotic plaque formation(P<0.05).Conclusion Cys-C and Hcy have some correlation with the occurrence and development of carotid atherosclerosis.CTA can effectively show the degree of carotid atherosclerosis in patients with ischemic cerebrovascular disease and it has a significant effect on the early assessment of ischemic cerebrovascular disease.

关 键 词：缺血性脑血管疾病 CT血管成像 颈动脉粥样硬化 血清胱抑素C 同型半胱氨酸 

分 类 号：R743[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]