精氨酸谷氨酸盐注射液对慢性肝病伴高血氨患者的临床安全性与有效性研究  

Study on Clinical Safety and Efficacy of Arginine Glutamate Injection in Patients of Chronic Liver Disease with Hyperammonemia

作　　者：张兆红[1] 王瑶 段庆华 陈超 张旭[1] 唐徐佳 李亚兰 朱松涛[1] 黄智[1] Zhang Zhao-hong;Wang Yao;Duan Qing-hua;Chen Chao;Zhang Xu;Tang Xu-jia;Li Ya-lan;Zhu Song-tao;Huang Zhi(Department of Gastroenterology,People's Hospital of Guanghan City,Guanghan 618300,Sichuan Province,China)

机构地区：[1]广汉市人民医院消化内科,四川广汉618300

出　　处：《中国社区医师》2022年第3期13-15,共3页Chinese Community Doctors

基　　金：精氨酸谷氨酸盐注射液临床安全性与有效性研究(2020年广汉市重点科学技术研究项目,项目编号:GH2020SFY04)。

摘　　要：目的:探讨精氨酸谷氨酸盐注射液治疗慢性肝病伴高血氨患者的有效性和安全性。方法:选取2020年6月-2021年4月广汉市人民医院收治的慢性肝病伴高血氨患者100例,采用随机数字表法分为两组,各50例。对照组给予盐酸精氨酸注射液治疗,研究组给予精氨酸谷氨酸盐注射液治疗,比较两组治疗效果。结果:两组血氨下降的百分率及治疗总效率比较,差异均无统计学意义(P>0.05);研究组治疗1周后临床症状及体征积分均低于对照组,差异有统计学意义(P<0.05);研究组临床症状及体征积分改善总有效率明显高于对照组,差异有统计学意义(P<0.05);两组均未见药物相关不良反应。结论:精氨酸谷氨酸盐注射液治疗慢性肝病伴血氨升高,可显著降低血氨水平,改善患者临床症状和体征,且具有较高的安全性。Objective:To explore the efficacy and safety of arginine glutamate injection in the treatment of chronic liver disease with hyperammonemia.Methods:A total of 100 patients with chronic liver disease and hyperammonemia who were admitted to the People's Hospital of Guanghan City from June 2020 to April 2021 were selected and divided into two groups by random number table method,with 50 cases in each group.The control group was treated with arginine hydrochloride injection.The study group received arginine glutamate injection.The therapeutic effects between the two groups were compared.Results:The percentage of blood ammonia decrease and the total treatment efficiency of the two groups were compared,the difference was not statistically significant(P>0.05).The score of clinical symptoms and signs in the study group was lower than that in the control group after 1 week of treatment,the differences were statistically significant(P<0.05).The total effective rate for the score improvement of clinical symptoms and signs in the study group was significantly higher than that in the control group,the differences were statistically significant(P<0.05).There were no drug-related adverse reactions in both groups.Conclusion:Arginine glutamate injection in the treatment of chronic liver disease with elevated blood ammonia can significantly reduce the level of blood ammonia,improve clinical symptoms and signs of patients,and has a high safety.

关 键 词：精氨酸谷氨酸盐注射液 慢性肝病 血氨 安全性 

分 类 号：R575[医药卫生—消化系统] R747.9[医药卫生—内科学]