米安色林联合氨磺必利治疗精神分裂症阴性症状疗效观察  

Observation on curative effect of mianserin combined with amisulpride in the treatment of negative symptoms of schizophrenia and its influence on social function

作　　者：严琦[1] 丁雅琴[1] 张沛云 刘超 Yan Qi;Ding Yaqin;Zhang Peiyun;Liu Chao(Department of psychiatry,the fourth people's hospital of Nantong city,Nantong,Jiangxi,226000,China)

机构地区：[1]南通市第四人民医院精神二科,江苏南通226000

出　　处：《齐齐哈尔医学院学报》2021年第24期2141-2144,共4页Journal of Qiqihar Medical University

基　　金：2016年南通市市级科技计划项目(GJZ16038)。

摘　　要：目的探讨米安色林联合氨磺必利治疗精神分裂症阴性症状疗效及对患者社会功能和生活质量的影响。方法选择2019年1月-2021年1月在本院接受治疗的62例精神分裂症阴性症状患者作为研究对象,按随机数表法分为观察组和对照组两组,每组各31例。对照组患者口服氨磺必利,观察组在口服氨磺必利基础上加用盐酸米安色林片。两组疗程均为12周。比较两组患者治疗疗效,治疗前、治疗4周、治疗8周和治疗12周阴性症状量表(SANS)评分、社会功能缺陷量表(SDSS)评分和生活质量评定量表(SF-36)评分,及不良反应情况。结果观察组患者术后治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗4周、8周和12周后,两组患者的SANS评分低于治疗前,差异具有统计学意义(P<0.05);且观察组患者SANS评分则低于对照组,差异具有统计学意义(P<0.05);治疗4周、8周和12周后,两组患者的SDSS评分低于治疗前,差异具有统计学意义(P<0.05);且观察组患者SDSS评分则低于对照组,差异具有统计学意义(P<0.05);治疗4周、8周和12周后,两组患者的SF-36评分高于治疗前,差异具有统计学意义(P<0.05);且观察组患者SF-36评分则高于对照组,差异具有统计学意义(P<0.05);两组患者不良反应比较,差异无统计学意义(P>0.05)。结论米安色林联合氨磺必利治疗精神分裂症阴性症状疗效良好,且可改善患者社会功能和生活质量。Objective To investigate the curative effect of mianserin combined with amisulpride in the treatment of negative symptoms of schizophrenia and its influence on patients'social function and quality of life.Methods A total of 62 patients with negative symptoms of schizophrenia those admitted to our hospital from January 2019 to January 2021 were selected as the research objects.According to random numbers divided observation group and control group,31 cases in each group.The control group received amisulpride orally,and the observation group received mianserin hydrochloride tablets on the basis of amisulpride.The treatment course of the two groups was 12 weeks.To compare the therapeutic effects of the two groups,scores of scale for assessment of negative symptoms(SANS),social function deficiency scale(SDSS)score and medical outcomes study short-form 36(SF-36)score at 4th,8th,and 12thweek,and adverse reactions of the two groups were compared.Results The total effective rate of observation group was higher than that of control group(P<0.05).After 4 weeks,8 weeks and 12 weeks of treatment,SANS scores of patients with negative symptoms of schizophrenia of the two groups were lower than those before treatment(P<0.05).The SANS scores ofobservation group was lower than that of the control group(P<0.05).After treatment for 4 weeks,8 weeks and 12 weeks,SDSS scores of patients with negative symptoms of schizophrenia of the two groups were lower than those before treatment(P<0.05).The SDSS score of observation group was lower than the control group(P<0.05).After treatment for 4 weeks,8 weeks and 12 weeks,theSF-36 scores of the two groups were higher than those before treatment(P<0.05);the SF-36 score of observation group was higher than the control(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions Mianserin combined with amisulpride has a good effect on the treatment of negative symptoms of schizophrenia,and could improve the social function and quality of life of pati

关 键 词：米安色林 氨磺必利 精神分裂症 阴性症状 疗效 社会功能 生活质量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]