Interactions between remote ischemic conditioning and post-stroke sleep regulation  

作　　者：Xian Wang Xunming Ji 

机构地区：[1]Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Capital Medical University,Beijing,100069,China [2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine,Beijing,100069,China

出　　处：《Frontiers of Medicine》2021年第6期867-876,共10页医学前沿（英文版）

基　　金：supported by the National Key R&D Program of China(No.2017YFC1308401);the Talent Introduction Project of the Beijing Bureau of Foreign Expert(No.BJ2018001).

摘　　要：Sleep disturbances are common in patients with stroke,and sleep quality has a critical role in the onset and outcome of stroke.Poor sleep exacerbates neurological injury,impedes nerve regeneration,and elicits serious complications.Thus,exploring a therapy suitable for patients with stroke and sleep disturbances is imperative.As a multi-targeted nonpharmacological intervention,remote ischemic conditioning can reduce the ischemic size of the brain,improve the functional outcome of stroke,and increase sleep duration.Preclinical/clinical evidence showed that this method can inhibit the inflammatory response,mediate the signal transductions of adenosine,activate the efferents of the vagal nerve,and reset the circadian clocks,all of which are involved in sleep regulation.In particular,cytokines tumor necrosis factorα(TNFα)and adenosine are sleep factors,and electrical vagal nerve stimulation can improve insomnia.On the basis of the common mechanisms of remote ischemic conditioning and sleep regulation,a causal relationship was proposed between remote ischemic conditioning and post-stroke sleep quality.

关 键 词：remote ischemic conditioning sleep regulation STROKE 

分 类 号：R743.3[医药卫生—神经病学与精神病学]