^(18)F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma  

作　　者：Chao Lu Kailiang Wang Fei Meng Yihe Wang Yongzhi Shan Penghu Wei Guoguang Zhao 

机构地区：[1]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,100053,China [2]China International Neuroscience Institute(CHINA-INI),Beijing,100053,China [3]Center of Epilepsy,Beijing Institute for Brain Disorder,Beijing,100069,China

出　　处：《Frontiers of Medicine》2021年第6期913-921,共9页医学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81801288,81871009,and 82030037)。

摘　　要：Epileptogenic hypothalamic hamartoma is characterized by intractable gelastic seizures.A systematic analysis of the overall brain metabolic pattern in patients with hypothalamic hamartoma(HH)could facilitate the understanding of the epileptic brain network and the associated brain damage effects of HH.In this study,we retrospectively evaluated 27 patients with epileptogenic HH(8 female patients;age,2–33 years)by using ^(18)F-fluorodeoxyglucose-positron emission tomography.The correlations among tomography result,seizure type,sex,and structural magnetic resonance imaging were assessed.Whole metabolic patterns and voxel-based morphometry findings were assessed by group analysis with healthy controls.Assessment of the whole metabolic pattern in patients with HH revealed several regional metabolic reductions in the cerebrum and an overall metabolic reduction in the cerebellum.In addition,areas showing hypometabolism in the neocortex were more widely distributed ipsilaterally than contralaterally to the HH.Reductions in glucose metabolism and gray matter volume in the neocortex were predominant ipsilateral to the HH.In conclusion,the glucose hypometabolism pattern in patients with epileptogenic HH involved the neocortex,subcortical regions,and cerebellum.The characteristics of glucose hypometabolism differed across seizure type and sex.Reductions in glucose metabolism and structural changes may be based on different mechanisms,but both are likely to occur ipsilateral to the HH in the neocortex.We hypothesized that the dentato-rubro-thalamic tract and cerebro-ponto-cerebellar tract,which are responsible for intercommunication between the cerebral cortex,subcortical regions,and cerebellar regions,may be involved in a pathway related to seizure propagation,particularly gelastic seizures,in patients with HH.

关 键 词：hypothalamic hamartoma gelastic seizure fluorodeoxyglucose-positron emission tomography voxel-based morphometry 

分 类 号：R739.41[医药卫生—肿瘤]