晶状体衰老机制的研究  

Research on the mechanism of lenticular senescence

作　　者：付宇姗 周南[1] 齐艳华[1] Fu Yushan;Zhou Nan;Qi Yanhua(Department of Ophthalmology,the Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院眼科,150086

出　　处：《国际眼科纵览》2021年第6期529-534,共6页International Review of Ophthalmology

摘　　要：晶状体上皮细胞是晶状体代谢的中枢,其衰老会导致白内障的发生。晶状体上皮细胞端粒长度的缩短、细胞内氧化应激状态的长期存在并激活多条炎症通路、细胞自噬活性的降低以及抗衰老酶SIRT的失活均参与疾病发展过程。同时晶状体内蛋白质、脂质稳态的破坏以及水平衡失衡等均会加速晶状体衰老进程。Lens epithelium is the center of lens metabolism,and its senescence will lead to cataract.Several mechanisms are involved in the progression of cataract including:shortening of telomere length in lens epithelial cells,the long-term existence of intracellular oxidative stress activating multiple inflammatory pathways involved in cell signaling,decreased autophagy activity,and the inactivation of the anti-aging enzyme-SIRT.Meanwhile,the damage of protein and lipid homeostasis in lens and the imbalance of water balance will accelerate the process of lens aging.

关 键 词：白内障 晶状体上皮细胞 晶状体衰老 

分 类 号：R776[医药卫生—眼科]