腹腔镜手术对结直肠癌患者氧化应激反应及免疫功能的影响  

Effects of laparoscopic surgery on oxidative stress response and immune function in patients with colorectal cancer

作　　者：冯振华[1] 陈颖[2] FENG Zheng-hua;CHEN Ying(General Surgery 2nd Ward,Jiaozuo 2nd People's Hospital,Jiaozuo 454000,Henan,China)

机构地区：[1]焦作市第二人民医院普通外科二病区,河南焦作454000 [2]焦作市人民医院药物临床试验机构

出　　处：《中国校医》2021年第12期937-939,共3页Chinese Journal of School Doctor

摘　　要：目的探讨结直肠癌患者应用腹腔镜手术治疗对氧化应激反应及免疫功能的影响。方法选取2018年7月—2020年1月于我院就诊的84例结直肠癌患者,采用随机数字表法分为两组,每组各42例。对照组采用开腹根治术治疗,观察组采用腹腔镜根治术治疗。对比两组氧化应激反应[超氧化物歧化酶(SOD)、血浆丙二醛(MDA)]和免疫功能[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)],以及并发症发生情况。结果观察组SOD水平为(91.75±6.37)U/mL高于对照组的(70.26±5.49)U/mL,MDA水平为(5.11±0.93)nmol/mL低于对照组的(7.49±1.06)nmol/mL,差异有统计学意义(t=16.562、10.938,P<0.001);观察组CD4^(+)水平为(45.78±8.62)%、CD8^(+)水平为(29.26±5.66)%、CD4^(+)/CD8^(+)水平为(1.13±0.15),高于对照组的(28.69±6.39)%、(22.36±4.25)%、(0.97±0.02)%,差异有统计学意义(t=10.328、6.318、6.852,P<0.001);观察组并发症发生率(4.76%)较对照组(21.42%)低,差异有统计学意义(χ^(2)=5.126,P=0.024)。结论结直肠癌患者应用腹腔镜手术治疗可有效减轻氧化应激反应,对免疫功能影响较小,并发症发生率较少,利于患者术后恢复。ObjectiveTo investigate the effect of laparoscopic surgery on oxidative stress and immune function in patients with colorectal cancer.MethodsFrom July 2018 to January 2020,84 patients with colorectal cancer were divided into a control group and an observation group by using the random number table method,with 42 cases in each group.The control group was treated by radical laparotomy,and the observation group was treated by laparoscopic radical surgery.The oxidative stress responses[superoxide dismutase (SOD),plasma malondialdehyde (MDA)]and immune function (CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),and complications were compared between the two groups.ResultsThe average SOD level in the observation group was (91.75±6.37) U/mL,higher than that in the control group:(70.26±5.49),the average MDA level in the observation group was (5.11±0.93) nmol/mL,lower than that in the control group:(7.49±1.06) nmol/mL,and the differences were statistically significant (t=16.562,10.938,both P<0.001).In the observation group,the average CD4^(+) level was (45.78±8.62)%,the CD8^(+) level was (29.26±5.66)%,and the CD4^(+)/CD8^(+)level was (1.13±0.15),which were higher than those in the control group:(28.69±6.39),(22.36±4.25),and (0.97±0.02),and the differences were statistically significant (t=10.328,6.318,6.852,all P<0.001).The incidence of complications in the observation group was 4.76%,which was lower than that in the control group (21.42%),and the difference was statistically significant (χ^(2)=5.126,P=0.024).ConclusionLaparoscopic surgery can effectively reduce oxidative stress in colorectal cancer patients,it has little effect on immune function,and the incidence of complications is low.Therefore,it is beneficial to the postoperative recovery of the patients.

关 键 词：结直肠癌 腹腔镜手术 氧化应激 免疫功能 并发症 

分 类 号：R735.3[医药卫生—肿瘤]