NUSAP1在膀胱尿路上皮癌组织中表达与淋巴结转移的关系  

Relationship between expression of NUSAP1 in Bladder urothelial carcinoma and lymph node metastasis

作　　者：刘革新 刘盼 汤乘 LIU Gexin;LIU Pan;TANG Cheng(Department of Emergency, The Affiliated Zhuzhou Hospital of Xiangya Medical College, CSU, Zhuzhou 412007, Hunan,China;Department of Urology, The Affiliated Zhuzhou Hospital of Xiangya Medical College, CSU, Zhuzhou 412007, Hunan, China)

机构地区：[1]中南大学湘雅医学院附属株洲医院急诊科,湖南株洲412007 [2]中南大学湘雅医学院附属株洲医院泌尿外科,湖南株洲412007

出　　处：《西部医学》2022年第2期240-244,共5页Medical Journal of West China

摘　　要：目的探讨核仁纺锤体相关蛋白1(NUSAP1)在膀胱尿路上皮癌(BUC)组织中的表达情况和其与临床病理参数及淋巴结转移的关系。方法选取中南大学湘雅医学院附属株洲医院2017年1月1日~2020年8月31日行膀胱癌根治性切除术后病理标本103例为观察组,另外从103例标本中随机选取50例癌旁正常膀胱组织标本为对照组。采用免疫组化检测NUSAP1在膀胱癌组织中的表达情况,分析NUSAP1表达同膀胱癌患者临床病理参数以及淋巴结转移之间的关系。结果观察组及对照组NUSAP1阳性表达率组间比较,差异有统计学意义(P<0.05)。NUSAP1表达水平与BUC患者肿瘤直径、肿瘤个数、病理分级、淋巴结转移和临床分期显著相关(P<0.05)。淋巴结转移与肿瘤的直径、肿瘤个数、病理分级、临床分期和NUSAP1表达水平显著相关(P<0.05),Logistic多因素回归分析显示,仅NUSAP1表达水平是BUC淋巴结转移的独立影响因子(OR=1.951,95%CI 1.094~3.477,P=0.023)。结论NUSAP1在BUC组织中高表达,为淋巴结转移的独立预测因子。Objective This study explored nucleolar and spindle associated protein 1(NUSAP1)in the bladder urothelium cancer(Bladder urothelial carcinoma,BUC)tissue expression and its relationship with clinicopathological parameters and lymph node metastasis.Methods 103 cases of pathological specimens of radical resection of bladder cancer were selected from January 1,2017 to August 31,2020.50 normal bladder tissues were selected.The expression of NUSAP1 in bladder cancer tissues was detected by immunohistochemistry.The clinical pathological parameters of NUSAP1 expression in bladder cancer patients were analyzed.And the relationship between lymph node metastasis.Results The positive expression rate of NUSAP1 was(88/103)85.4%and(11/50)22.0%in BUC tissues and normal bladder tissues,respectively(P<0.05).The expression level of NUSAP1 was significantly correlated with tumor diameter,tumor number,pathological grade,lymph node metastasis and clinical stage in BUC patients(P<0.05).Lymph node metastasis was significantly associated with tumor diameter,number of tumors,pathological grade,clinical stage,and NUSAP1 expression level(P<0.05).Logistic multivariate regression analysis showed that only NUSAP1 expression level was an independent factor affecting BUC lymph node metastasis(OR:1.951,95%CI:1.094-3.477,P=0.023).Conclusion NUSAP1 is highly expressed in BUC tissues and is an independent predictor of lymph node metastasis.

关 键 词：核仁纺锤体相关蛋白1 膀胱尿路上皮癌 免疫组化 淋巴结转移 

分 类 号：R737.1[医药卫生—肿瘤]