前列腺癌中PCDH9与CyclinD1 C-myc表达的相关性及意义  被引量:3

The correlation and significance of PCDH9,cyclinD1 and C-myc expression in prostate cancer

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作  者:龙琼先 伍季[2] 彭勇 张旭乾 刘欣雅 LONG Qiongxian;WU Ji;PENG Yong;ZHANG Xuqian;LIU Xinya(Department of Pathology, Nanchong Central Hospital, North Sichuan Medical University, Nanchong 637000, Sichuan, China;Department of Urological Surgery, Nanchong Central Hospital, North Sichuan Medical University, Nanchong 637000, Sichuan, China;Department of Gynaecology and Obstetrics, Nanchong Central Hospital, North Sichuan Medical University, Nanchong 637000, Sichuan, China)

机构地区:[1]南充市中心医院·川北医学院第二临床医学院病理科,四川南充637000 [2]南充市中心医院·川北医学院第二临床医学院泌尿外科,四川南充637000 [3]南充市中心医院·川北医学院第二临床医学院妇产科,四川南充637000

出  处:《西部医学》2022年第2期260-264,共5页Medical Journal of West China

基  金:四川省卫生健康委员会科研课题(20PJ297)。

摘  要:目的探讨前列腺癌组织中原钙黏蛋白9(PCDH9)与细胞周期调控基因CyclinD1和C-myc蛋白表达的相关性,分析前列腺癌中PCDH9在调节肿瘤细胞周期及促进肿瘤进展中的作用。方法收集南充市中心医院2018~2020年间存档的92例前列腺癌及36例良性前列腺的石蜡包埋组织,采用免疫组织化学染色检测前列腺癌和良性前列腺组织中PCDH9和细胞周期调控基因CyclinD1和C-myc的表达情况,并分析其与临床病理特征的关系。结果PCDH9蛋白在前列腺癌组织中的阳性率明显低于良性前列腺组织(P<0.05)。前列腺癌组织中CyclinD1及C-myc的阳性表达率明显高于良性前列腺组织(P<0.05)。不同WHO/ISUP分级分组、PSA水平、临床分期的前列腺癌患者间PCDH9的阳性表达率差异有统计学意义(P<0.05),高WHO/ISUP分级分组、PSA>20ng/mL及Ⅲ+Ⅳ期前列腺癌患者PCDH9阳性率明显降低(P<0.05)。PCDH9表达与患者年龄、脉管神经侵犯无关(P>0.05)。前列腺癌患者CyclinD1和C-myc表达与WHO/ISUP分级分组、脉管侵犯、PSA水平及临床分期等相关(P<0.05),但不同年龄组及有无神经侵犯间的表达差异无统计学意义(P>0.05)。在有CyclinD1或C-myc表达的前列腺癌组织中存在PCDH9表达的缺失,PCDH9的表达与CyclinD1、C-myc的表达呈负相关(r=0.414~0.457,P<0.01)。结论前列腺癌组织中PCDH9呈低表达,且与细胞周期调控基因CyclinD1和C-myc的表达呈负相关,PCDH9可能通过调节细胞周期蛋白,进而促进肿瘤的进展和转移。Objective To evaluate the correlation between PCDH9 and the cell cycle regulation protein(CyclinD1 and C-myc)and explore the role of PCDH9 in regulating cell cycle and promoting tumor progression in the prostate cancer tissues.Methods 92 cases prostate cancer and 36 cases benign prostate samples were collected.PCDH9,CyclinD1 and C-myc protein were detected by immunohistochemical method.Results The positive rate of PCDH9 in prostate cancer tissues(72.8%)was significantly lower than that in benign prostate tissues(100%).The positive expression rates of CyclinD1 and C-myc in prostate cancer tissues were 68.5%and 64.1%,which were significantly higher than those in benign prostate tissues.The positive rates of PCDH9 in prostate cancer patients with different WHO/ISUP classification,PSA level,different clinical stages were statistically significant(P<0.05).The positive rates of PCDH9 in prostate cancer patients with Gleason score increased,PSA>20 ng/mL and high clinical stage(Ⅲ+Ⅳ)decreased significantly.The expression of PCDH9 was negatively correlated with the expression of CyclinD1 and C-myc in prostate cancer tissues(r=0.414 and 0.457,P<0.01).Conclusion PCDH9 is low expression in prostate cancer tissues,and negatively correlated with the expression of cell cycle regulation genes CyclinD1 and C-myc.PCDH9 may promote tumor progression and metastasis by regulating cell cycle protein.

关 键 词:前列腺癌 PCDH9 CYCLIND1 C-MYC 

分 类 号:R737.25[医药卫生—肿瘤]

 

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